Neurology
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Randomized Controlled Trial Comparative Study Clinical Trial
Opioids versus antidepressants in postherpetic neuralgia: a randomized, placebo-controlled trial.
Tricyclic antidepressants (TCA) provide less than satisfactory pain relief for postherpetic neuralgia (PHN), and the role of opioids is controversial. ⋯ Opioids effectively treat PHN without impairing cognition. Opioids and TCA act via independent mechanisms and with varied individual effect.
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Meta Analysis Comparative Study
An assessment of guidelines for prevention of ischemic stroke.
To compare methods and key management recommendations from recent stroke prevention guidelines. ⋯ Current stroke prevention guidelines do not provide adequate methodologic information to permit assessment of their quality, potential bias, and clinical applicability. Management recommendations are relatively consistent but differ in several important areas.
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Comparative Study
Features of medication overuse headache following overuse of different acute headache drugs.
To investigate pharmacologic features such as mean critical duration until onset of medication-overuse headache (MOH) (MCDO), mean critical monthly intake frequencies (MCMIF), and mean critical monthly dosages (MCMD) as well as specific clinical features of MOH after overuse of different acute headache drugs, with a focus on newly approved triptans. ⋯ Overuse of triptans leads to MOH faster and with lower dosages compared with ergots and analgesics. Clinical features of MOH depend on the type of overused headache medication. Pharmacologic and clinical characteristics of triptan-induced MOH call for the renewal of the current IHS classification.