Neurology
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Pregabalin for the treatment of postherpetic neuralgia: a randomized, placebo-controlled trial.
To evaluate the efficacy and safety of pregabalin in the treatment of postherpetic neuralgia (PHN). ⋯ Treatment of PHN with pregabalin is safe, efficacious in relieving pain and sleep interference, and associated with greater global improvement than treatment with placebo.
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Randomized Controlled Trial Comparative Study Clinical Trial
Venlafaxine versus imipramine in painful polyneuropathy: a randomized, controlled trial.
Tricyclic antidepressants (TCA) are often used in the treatment of painful polyneuropathy. Venlafaxine is a serotonin and weak noradrenaline reuptake inhibitor antidepressant with a different profile of other pharmacologic actions from those of TCA. ⋯ Venlafaxine relieves pain in polyneuropathy and may be as effective as imipramine.
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While a genetic risk factor for late-onset AD, the effects of the epsilon4 allele of the APOE gene on cognitive functioning more generally remain unclear. ⋯ APOE-epsilon4 is associated with cognitive decline among a high-functioning elderly cohort, with effects most pronounced after 7 years of follow-up. Hence, the epsilon4 allele either may function as a risk factor for cognitive impairment in normal aging across a broad spectrum of domains or may exert detectable effects early in a long prodromal AD trajectory.