Neurology
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Randomized Controlled Trial Multicenter Study Comparative Study
Efficacy of cabergoline in restless legs syndrome: a placebo-controlled study with polysomnography (CATOR).
To assess the efficacy and safety of the dopamine agonist cabergoline in the treatment of patients with idiopathic restless legs syndrome (CATOR study). ⋯ Single-evening cabergoline is an efficacious and well-tolerated short-term therapy for sensorimotor symptoms of restless legs syndrome and associated sleep disturbances.
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Randomized Controlled Trial Comparative Study Clinical Trial
High-frequency chest wall oscillation in ALS: an exploratory randomized, controlled trial.
To evaluate changes in respiratory function in patients with ALS after using high-frequency chest wall oscillation (HFCWO). ⋯ High-frequency chest wall oscillation was well tolerated, considered helpful by a majority of patients, and decreased symptoms of breathlessness. In patients with impaired breathing, high-frequency chest wall oscillation decreased fatigue and showed a trend toward slowing the decline of forced vital capacity.
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Comparative Study
Evidence of publication bias in reporting acute stroke clinical trials.
To ascertain the extent of publication bias in the reporting of acute stroke clinical trials. ⋯ Publication bias is evident in the acute stroke research literature, supporting the need for prospective trial registration.
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Comparative Study Clinical Trial
Noninvasive positive-pressure ventilation in ALS: predictors of tolerance and survival.
To identify factors associated with tolerance and survival after noninvasive positive-pressure ventilation (NIPPV) and to investigate the influence of NIPPV on lung function in patients with ALS. ⋯ Survival after noninvasive ventilation was independently related to ventilatory use (>or=4 h/day) and to the modifications of forced vital capacity decline after treatment initiation. The severity of bulbar impairment and the nutritional status of the ALS patients at the introduction of ventilation may predict tolerance and survival.