Neurology
-
We prospectively investigated the diagnostic accuracy of contrast-free 3-dimensional time-of-flight magnetic resonance angiography (3D-TOF-MRA) with volume rendering (VR) at 3.0 T to detect intracranial aneurysms in a large cohort of patients. ⋯ VR 3D-TOF-MRA at 3.0 T accurately identified the presence of intracranial aneurysms. High PPV and NPV indicated that VR 3D-TOF-MRA at 3.0 T may replace DSA as a contrast-free, noninvasive, and non-radiation-based modality for the diagnosis and screening of intracranial aneurysms.
-
Major effort and expense are devoted to faculty recruitment. Subsequent direction, support, and guidance of faculty members for retention and academic advancement are often inconsistent and ineffective. Individual mentorship is widely endorsed as an important element in advancement but often does not occur or is uneven in its pragmatic benefit. ⋯ A 100% response rate was achieved. The results of the survey demonstrated high levels of acceptance by faculty members and described benefits experienced by faculty, including better understanding of promotion and tenure policies and specific actions taken to achieve professional goals. An academic advisory committee can be a valuable adjunct to individual mentorship and to meetings with department chairs to enhance faculty satisfaction and advancement of neurology faculty members.
-
While most often transient, brachial plexus birth injury can cause permanent neurologic injury. The major risk factors for brachial plexus birth injury are fetal macrosomia and shoulder dystocia. ⋯ Microsurgical repair options include nerve grafts and nerve transfers. All children with brachial plexus birth injury require ongoing physical and occupational therapy and close follow-up to monitor progress.
-
Editorial Comment
Outcome prediction after cardiac arrest: new game, new rules.
-
Randomized Controlled Trial
A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease.
Lowering cholesterol is associated with reduced CNS amyloid deposition and increased dietary cholesterol increases amyloid accumulation in animal studies. Epidemiologic data suggest that use of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) may decrease the risk of Alzheimer disease (AD) and a single-site trial suggested possible benefit in cognition with statin treatment in AD, supporting the hypothesis that statin therapy is useful in the treatment of AD. ⋯ This study provides Class I evidence that simvastatin 40 mg/day does not slow decline on the ADAS-Cog.