Neurology
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Randomized Controlled Trial
Triptan-induced disruption of trigemino-cortical connectivity.
The 5-HT1B/D agonists (triptans) are specific headache medications that have no effect on pain as such. Although they are routinely used in the treatment of acute migraine attacks, the underlying mechanisms of action are still a matter of debate. ⋯ These data suggest that a specific functional inhibition of trigemino-cortical projections is one of the reasons that triptans, unlike pain killers, act highly specifically on headache and migraine but not pain as such.
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To examine the pricing trajectories in the United States of disease-modifying therapies (DMT) for multiple sclerosis (MS) over the last 20 years and assess the influences on rising prices. ⋯ MS DMT costs have accelerated at rates well beyond inflation and substantially above rates observed for drugs in a similar biologic class. There is an urgent need for clinicians, payers, and manufacturers in the United States to confront the soaring costs of DMTs.
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Randomized Controlled Trial
Etanercept in Alzheimer disease: A randomized, placebo-controlled, double-blind, phase 2 trial.
To determine whether the tumor necrosis factor α inhibitor etanercept is well tolerated and obtain preliminary data on its safety in Alzheimer disease dementia. ⋯ This study shows Class I evidence that weekly subcutaneous etanercept is well tolerated in Alzheimer disease dementia.