Neurology
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Editorial Comment
Fitness, depression, and poststroke fatigue: worn out or weary?
Each year, around 15 million people worldwide have a stroke. Of these, at least 5 million die, a third remain disabled, and the remainder make a good recovery.(1) Yet more than half of all these 10 million survivors will have fatigue, one of the most debilitating, but least studied, poststroke symptoms. Poststroke fatigue (PSF) is a multifaceted phenomenon.(2) It has been correlated with lowered mood, as well as being influenced by other factors, like age, sex, and cognition. Many researchers have demonstrated that the presence of fatigue negatively influences quality of life, return to work, and perhaps mortality.(3,4) However, most studies have been conducted cross-sectionally, in the subacute or chronic phase after stroke.(4-6.)
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Review Case Reports Comparative Study
Copy number variants are frequent in genetic generalized epilepsy with intellectual disability.
We examined whether copy number variants (CNVs) were more common in those with a combination of intellectual disability (ID) and genetic generalized epilepsy (GGE) than in those with either phenotype alone via a case-control study. ⋯ This study shows that CNVs are common in those with ID-GGE with recurrent deletions at 15q13.3, 15q11.2, and 16p13.11, particularly enriched compared with individuals with GGE or ID alone. Recurrent CNVs are likely to act as risk factors for multiple phenotypes not just at the population level, but also in any given individual. Testing for CNVs in ID-GGE will have a high diagnostic yield in a clinical setting and will inform genetic counseling.
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To evaluate the risk of Parkinson disease (PD) among patients with depression by using the Taiwan National Health Insurance Research Database (NHIRD). ⋯ The likelihood of developing PD is greater among patients with depression than patients without depression. Depression may be an independent risk factor for PD.
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Migraine is associated with white matter hyperintensities (WMH) cross-sectionally, but its effect on WMH progression is uncertain. ⋯ Migraine is associated with WMH volume cross-sectionally but not with WMH progression over time. This suggests that the association between migraine and WMH is stable in older age and may be primarily attributable to changes occurring earlier in life, although further work is needed to confirm these findings.
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Comparative Study
Long-term outcomes of epilepsy surgery in Sweden: a national prospective and longitudinal study.
To investigate prospective, population-based long-term outcomes concerning seizures and antiepileptic drug (AED) treatment after resective epilepsy surgery in Sweden. ⋯ This study provides Class III evidence that more patients are seizure-free and have stopped AED treatment in the long term after resective epilepsy surgery than nonoperated epilepsy patients.