Neurology
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To assess the relationship between regional brain volume changes and traumatic brain injury (TBI) severity in patients with and without focal lesions. ⋯ Patterns of parenchymal volumetric changes can differentiate among levels of traumatic brain injury (TBI) severity, even in mild TBI. TBI causes a spatially extensive pattern of volume loss that reflects independent but overlapping contributions of focal and diffuse injury.
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Historical Article
The history of progressive muscular atrophy: syndrome or disease?
Since its first description more than a century ago, there has been much debate about the diagnostic entity progressive muscular atrophy (PMA). Initially, PMA included all forms of progressive amyotrophy. ⋯ In contrast, several observations provided evidence that PMA can be linked both clinically and pathologically to ALS. Therefore, PMA should be considered as a syndromal subtype within a clinical spectrum of motor neuron diseases.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Levetiracetam for the treatment of idiopathic generalized epilepsy with myoclonic seizures.
Currently, there are no published randomized controlled trials evaluating the efficacy and safety of adjunctive antiepileptic therapy in idiopathic generalized epilepsy with myoclonic seizures. ⋯ These results suggest that levetiracetam is an effective and well-tolerated adjunctive treatment for patients with previously uncontrolled idiopathic generalized epilepsy with myoclonic seizures.