Neurology
-
Randomized Controlled Trial Multicenter Study Clinical Trial
Levetiracetam for the treatment of idiopathic generalized epilepsy with myoclonic seizures.
Currently, there are no published randomized controlled trials evaluating the efficacy and safety of adjunctive antiepileptic therapy in idiopathic generalized epilepsy with myoclonic seizures. ⋯ These results suggest that levetiracetam is an effective and well-tolerated adjunctive treatment for patients with previously uncontrolled idiopathic generalized epilepsy with myoclonic seizures.
-
To characterize differences in the prevalence of thrombophilic variables in a large cohort of patients with cerebral venous sinus thrombosis (CVST) and lower extremity deep vein thrombosis (DVT). ⋯ The prevalence of selected thrombophilia factors differs comparing patients with cerebral venous sinus thrombosis and deep vein thrombosis. These differences may offer insights into mechanisms governing the geographic distribution of venous thrombosis.
-
Randomized Controlled Trial Multicenter Study
Oxcarbazepine in migraine headache: a double-blind, randomized, placebo-controlled study.
To evaluate the efficacy, safety, and tolerability of oxcarbazepine (1,200 mg/day) vs placebo as prophylactic therapy for patients with migraine headaches. ⋯ Overall, oxcarbazepine was safe and well tolerated; however, oxcarbazepine did not show efficacy in the prophylactic treatment of migraine headaches.
-
To assess and compare the extent to which comorbid conditions explain the role disability associated with migraine and other severe headaches. ⋯ Comorbidity is an important factor in understanding disability among persons with headache.