Neurology
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To describe the emerging profile of headache frequency following a 2-month drug-free period in patients with medication overuse. ⋯ These data demonstrate the benefit of withdrawal in already established medication overuse and support the existence of medication-overuse headache as a clinical entity.
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To investigate the molecular genetic basis of cluster headache (CH), using a genome-wide scan and candidate gene strategy. ⋯ Cluster headache is a complex genetic disorder, with possible phenotypic and genetic heterogeneity compounding attempts at gene identification.
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Clinical Trial
Rapid infusion of cold saline (4 degrees C) as adjunctive treatment of fever in patients with brain injury.
The use of rapid infusion of large-volume cold saline (CS) as an adjunctive therapy for treating refractory fever in nine patients is reported. A decline in temperature (39.2 +/- 0.3 vs 37.1 +/- 1.2 degrees C, p = 0.006) at 2 hours and fever burden (97.3 +/- 343.8 vs 734.3 +/- 422.3 degrees C*min, p = 0.02) at 12 hours was noted after CS bolus. Rapid infusion of large-volume CS may be used as an adjunct for inducing normothermia in refractory febrile patients.