Neurology
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Editorial Comment Review
Lowering cholesterol in patients with stroke: raising the standard.
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Randomized Controlled Trial
Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage.
Although volume of intracerebral hemorrhage (ICH) is a predictor of mortality, it is unknown whether subsequent hematoma growth further increases the risk of death or poor functional outcome. ⋯ Hematoma growth is an independent determinant of both mortality and functional outcome after intracerebral hemorrhage. Attenuation of growth is an important therapeutic strategy.
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Randomized Controlled Trial Multicenter Study Comparative Study
A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses.
Teriflunomide, a dihydro-orotate dehydrogenase inhibitor, has immunomodulatory effects, including the ability to suppress experimental allergic encephalomyelitis. In this randomized, double-blind, placebo-controlled Phase II study, the authors examined the safety and efficacy of oral teriflunomide in multiple sclerosis (MS) with relapses. ⋯ Oral teriflunomide was effective in reducing MRI lesions and was well tolerated in patients with relapsing multiple sclerosis.