Neurology
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Clinical Trial Controlled Clinical Trial
Proton MRS reveals frontal lobe metabolite abnormalities in idiopathic generalized epilepsy.
To assess gamma-aminobutyric acid (GABA) plus homocarnosine (GABA+) and glutamate plus glutamine (GLX) concentrations in the frontal lobes of patients with idiopathic generalized epilepsy (IGE). ⋯ IGE was associated with bilateral frontal lobe metabolite changes. Elevation in GLX was observed, which may imply increased neuronal excitability, whereas reduction in NAAt suggests reduced overall neuronal numbers or neuronal dysfunction.
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Randomized Controlled Trial Clinical Trial
A randomized, double-blind, placebo controlled study on analgesic effects of botulinum toxin A.
Botulinum toxin type A (BTXA) is used to treat neurologic disorders associated with increased muscle tone. Its use is often associated with pain relief. ⋯ The results suggest that pain reduction after BTXA treatment is mediated through its effect on muscle tone rather than a direct analgesic effect.
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Case Reports
Painful vascular compression syndrome of the sciatic nerve caused by gluteal varicosities.
The authors report three patients with chronic sciatic pain without focal neurologic deficit. Sitting or lying on the affected side provoked pain, and standing and walking relieved it. ⋯ Decompression of the nerve resulted in complete and permanent pain relief. Sciatic or buttock pain in patients with varicosities and pain provocation in the sitting or lying position suggests this neurovascular compression syndrome.