Neurology
-
The authors hypothesized that central factors may underlie sensory deficits in patients with nondermatomal somatosensory deficits (NDSD) and that functional brain imaging would reveal altered responses in supraspinal nuclei. ⋯ Diminished perception of innocuous and noxious stimuli is associated with altered activity in many parts of the somatosensory pathway or other supraspinal areas. The cortical findings indicate a neurobiological component for at least part of the symptoms in patients presenting with nondermatomal somatosensory deficits.
-
Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Pregabalin for the treatment of postherpetic neuralgia: a randomized, placebo-controlled trial.
To evaluate the efficacy and safety of pregabalin in the treatment of postherpetic neuralgia (PHN). ⋯ Treatment of PHN with pregabalin is safe, efficacious in relieving pain and sleep interference, and associated with greater global improvement than treatment with placebo.
-
Randomized Controlled Trial Comparative Study Clinical Trial
Venlafaxine versus imipramine in painful polyneuropathy: a randomized, controlled trial.
Tricyclic antidepressants (TCA) are often used in the treatment of painful polyneuropathy. Venlafaxine is a serotonin and weak noradrenaline reuptake inhibitor antidepressant with a different profile of other pharmacologic actions from those of TCA. ⋯ Venlafaxine relieves pain in polyneuropathy and may be as effective as imipramine.