BMC anesthesiology
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High spinal block is a serious complication of spinal anesthesia. However, findings regarding its associated risk factors are inconsistent, and no studies have reported a relevant risk prediction score. We aimed to determine the risk prediction score for high spinal block in patients who were induced spinal anesthesia for cesarean delivery. ⋯ The combination of patient- and anesthesia-related predictors played an important role in the intermediate- and high-risk groups for high sensory spinal block. Addressing the modifiable risk factors-a GA < 35 weeks, an optimal dose of bupivacaine, and the experience level of the spinal block performer-could minimize the risk of high spinal block during cesarean delivery.
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Randomized Controlled Trial Comparative Study
Comparison of bougie-guided cricothyrotomy and traditional cricothyrotomy techniques in an obese 3D-printed surgical airway manikin: a randomized controlled study.
Obesity is one of the conditions that may require invasive airway management. The effectiveness of invasive airway techniques in obesity is not fully understood, and there is no routinely recommended technique. This study aimed to compare the first attempt success rate, procedure time, and difficulty of traditional surgical cricothyrotomy and bougie-guided cricothyrotomy on a 3D-printed surgical airway manikin made obese using simple techniques. ⋯ The manuscript has been presented 9th EurAsian Congress on Emergency Medicine (oral presentation) at the 9-12 November, 2023, Antalya, Turkey, and won the best oral abstract award at this congress.
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Randomized Controlled Trial Comparative Study
Comparative efficacy of ciprofol and propofol in reducing respiratory depression during ERCP anesthesia: a randomized controlled trial.
Propofol is one of the important drug causes of respiratory depression in endoscopic retrograde cholangiopancreatography (ERCP) anesthesia. This study aims to clarify whether Ciprofol in ERCP anesthesia reduces the respiratory depression rate. ⋯ For patients undergoing anesthesia for ERCP, Ciprofol, compared to Propofol, has been shown to effectively reduce the incidence of intraoperative respiratory depression, thereby enhancing the safety of the anesthesia process.
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Randomized Controlled Trial
The effects of dexmedetomidine on thiol/disulphide homeostasis in coronary artery bypass surgery: a randomized controlled trial.
Thiol-disulfide homeostasis (TDH) plays a pivotal role in various physiological mechanisms, including antioxidant defence, detoxification, apoptosis, regulation of enzyme activities and cellular signal transduction. TDH can be used as a biomarker to detect oxidative stress (OS) levels and ischemia status in the tissues. Coronary artery bypass grafting (CABG) surgery is a procedure associated with high oxidative stress. Dexmedetomidine, an alpha-2 agonist anaesthetic agent, has antioxidant effects. In this study, the effects of dexmedetomidine on oxidative stress in CABG surgery were investigated. ⋯ In patients receiving dexmedetomidine, lower postoperative levels of disulfide, disulfide/native thiol, and disulfide/total thiol, along with higher native thiol/total thiol, were observed compared to the control group. (p < 0.05) Postoperative native thiol and total thiol levels were similar for both groups. (p > 0.05) CONCLUSIONS: In our study, through dynamic thiol-disulfide measurements, we found that levels of oxidative stress (OS) were lower in patients who received dexmedetomidine. We believe that the positive effects of dexmedetomidine on OS could be beneficial in CABG surgery. Furthermore, we anticipate that with further studies conducted in larger patient cohorts, the clinical utilization of dexmedetomidine will become more widespread.
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Randomized Controlled Trial Multicenter Study
Ultrasound guided pediatric caudal dose: a two-center randomized controlled trial.
The drug volume to be used in caudal in pediatric patients has remained an unmet issue since long. We determined the minimum drug volume required to reach T10 level in pediatric patients using ultrasonography and compared it with the already established volume by Armitage formula. ⋯ A volume of 0.7 ml/kg of local anaesthetic in pediatric caudal block is sufficient to achieve a target of T10 level for infraumblical surgeries.