BMJ open
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It is fundamental that randomised controlled trials (RCTs) are properly conducted in order to reach well-supported conclusions. However, there is emerging evidence that RCTs are subject to biases which can overestimate or underestimate the true treatment effect, due to flaws in the study design characteristics of such trials. The extent to which this holds true in oral health RCTs, which have some unique design characteristics compared to RCTs in other health fields, is unclear. As such, we aim to examine the empirical evidence quantifying the extent of bias associated with methodological and non-methodological characteristics in oral health RCTs. ⋯ The intended audiences of the findings will include dental clinicians, oral health researchers, policymakers and graduate students. The aforementioned will be introduced to the findings through workshops, seminars, round table discussions and targeted individual meetings. Other opportunities for knowledge transfer will be pursued such as key dental conferences. Finally, the results will be published as a scientific report in a dental peer-reviewed journal.
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Comparative Study
Job stress and burnout in hospital employees: comparisons of different medical professions in a regional hospital in Taiwan.
To explore the prevalence and associated factors of burnout among five different medical professions in a regional teaching hospital. ⋯ Physician assistant is an emerging high burnout group; its severity is similar to that of nurses and far more than that of physicians, administrative staff and medical technicians. These findings may contribute to the development of feasible strategies to reduce the stress which results in the burnout currently plaguing most hospitals in Taiwan.
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Perioperative Ischaemic Evaluation-2 (POISE-2) is an international 2×2 factorial randomised controlled trial of low-dose aspirin versus placebo and low-dose clonidine versus placebo in patients who undergo non-cardiac surgery. Perioperative aspirin (and possibly clonidine) may reduce the risk of postoperative acute kidney injury (AKI). ⋯ NCT01082874.
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Multicenter Study Observational Study
Does neonatal pain management in intensive care units differ between night and day? An observational study.
To determine whether analgesic use for painful procedures performed in neonates in the neonatal intensive care unit (NICU) differs during nights and days and during each of the 6 h period of the day. ⋯ The substantial differences in the use of analgesics around-the-clock may be questioned on quality of care grounds.
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Observational Study
Factors associated with the clinical outcomes of paediatric out-of-hospital cardiac arrest in Japan.
To better understand and predict clinical outcomes of paediatric out-of-hospital cardiac arrest (OHCA). ⋯ For children who have OHCA from non-cardiac origin, bystander rescue breathing is mandatory to achieve CPC 1 or 2.