Masui. The Japanese journal of anesthesiology
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To evaluate in man the potentiation by nitrous oxide of the neuromuscular blockade produced by pancuronium, pancuronium 0.025, 0.035, 0.049 or 0.068 mg.kg-1 was given during thiamylal-fentanyl anesthesia with and without nitrous oxide, and the evoked electromyography (EMG) of hypothenar muscle was measured. In the group receiving nitrous oxide the ED50 and ED95 were 0.0359 and 0.0691 mg.kg-1. In the group not receiving nitrous oxide, these values were 0.0389 and 0.0849 mg.kg-1. ⋯ It was also revealed that the magnitude of the blockade was influenced by dose, gender, nitrous oxide, lean body mass and body surface area by the multiple regression analysis. DRS for the female patients shifted to the left, and the differences between both sexes seemed to decrease in the group receiving nitrous oxide. It is concluded that the results of the present study appears to be similar to those obtained in the previous study on vecuronium using EMG.
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The relative accuracy of Thermoscan PRO-1 (Thermoscan, USA), an infrared ear thermometer, in an unadjusted mode was examined in 21 patients under general anesthesia, using the esophageal and tympanic membrane temperatures as the reference values. The correlation coefficient between the temperature measured by Thermoscan PRO-1 and the esophageal temperature, and that between the temperature measured by Thermoscan PRO-1 and the tympanic membrane temperature, were 0.953 and 0.942, respectively (P < 0.01). The "limits of agreement" between the temperature measured by Thermoscan PRO-1 and esophageal temperature, and between the temperature measured by Thermoscan PRO-1 and tympanic membrane temperature, were -0.5-0.4 degrees C and -0.5-0.5 degrees C, respectively. We conclude that Thermoscan PRO-1 is sufficiently reliable for monitoring body temperature during surgery.