Masui. The Japanese journal of anesthesiology
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Clinical Trial Controlled Clinical Trial
[Continuous epidural buprenorphine for postoperative pain relief after thoracotomy].
To evaluate postoperative analgesia and side effects of epidural buprenorphine, 60 patients after thoracotomy were divided into 6 groups. All patients received a bolus epidural administration of buprenorphine 0.1 mg in 8 ml of 0.25% bupivacaine. Following this epidural bolus, 10 patients in each group were given 0.25% bupivacaine alone (group A), buprenorphine 5 micrograms in 1 ml of 0.25% bupivacaine (group B), buprenorphine 8 micrograms in 1 ml of 0.25% bupivacaine (group C), buprenorphine 12 micrograms in 1 ml of 0.25% bupivacaine (group D), buprenorphine 15 micrograms in 1 ml of 0.25% bupivacaine (group E) or buprenorphine 18 micrograms in 1 ml of 0.25% bupivacaine (group F) with a portable disposable device at a rate of 1 ml.h-1 for 48 h. ⋯ Those for the second 24 hours postoperatively in each group were 40%, 50%, 70%, 60%, 90%, and 90%, respectively. No significant difference in the incidence of side-effect was found among 6 groups. We concluded that optimal epidural doses of buprenorphine for post-thoracotomy pain relief are 15 and 18 micrograms.h-1 in the first and second 24 hours postoperatively, respectively.
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Clinical Trial
[Postoperative analgesia service by continuous epidural infusion with buprenorphine].
We examined the analgesic efficacy and side effects of continuous epidural infusion with buprenorphine in 340 surgical patients. The patients received epidural injection of 0.1 mg of buprenorphine in 8 ml of 0.25% bupivacaine immediately after surgery. The patients who underwent thoracotomy or intraabdominal surgery were subsequently infused with buprenorphine 15 micrograms in 1 ml of 0.25% buprenorphine at a rate of 1 ml.h-1 for 48 h. ⋯ Visual analogue scale (VAS) was 22 +/- 2 mm at rest and 43 +/- 2 mm at movement on the postoperative day 1. Corresponding values on the postoperative day 2 were 16 +/- 2 mm and 37 +/- 2 mm, respectively. Nausea and vomiting were found in 12.4% of the patients.
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A 27-year-old female with severe pulmonary hypertension was scheduled to undergo an elective cesarean section at the 32-week gestational age. Since the preoperative assessment revealed that the patient could not tolerate the hemodynamic changes during the operation under general anesthesia without any cardiopulmonary support, the percutaneous cardiopulmonary support (PCPS) with a centrifugal pump was applied for the anesthetic management of the patient during the operation. ⋯ The operation was finished uneventfully, and the patient could successfully emerge from the PCPS immediately after the operation. The PCPS is thought to be very useful for the anesthetic management of the patients with poor cardiopulmonary tolerance.