Masui. The Japanese journal of anesthesiology
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We studied leg pain experienced under spinal anesthesia in leprosy patients. Seven of twenty patients complained of the leg pain a few minutes after spinal block. The pain was localized in the parts of deafferentation or phantom limb, and was relatively mild and controllable. We consider that the inhibitory system is inactivated when the somatic impulse is blocked by spinal anesthesia, and as a result the abnormal burst activity of dorsal horn produced by peripheral nerve damage of leprosy causes phantom pain.
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The interaction of sevoflurane and nitrous oxide (N2O) on the MAC was studied in the four groups of patients between 30-60 years of age scheduled for laparotomies. Patients received one of four different concentrations of N2O [0% (n = 14), 25% (n = 16), 50% (n = 15), or 70% (n = 18)]. Anesthesia was induced with sevoflurane and N2O using a semiclosed circuit with a carbon dioxide absorber. ⋯ The extrapolated MAC value for N2O was 102%. The MAC values of sevoflurane in O2 and N2O were similar to the previously reported values. We conclude that in adults, N2O concentrations in the dose range 0-70% reduce sevoflurane MAC in a linearly additive manner.