Masui. The Japanese journal of anesthesiology
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Ketamine is associated with an increase in the bispectral index (BIS) values that can lead to an overdose of hypnotic agents. We investigated the effect of ketamine on BIS values during general anesthesia with a target-controlled infusion (TCI) of propofol and infusion of remifentanil. ⋯ Under stable propofol and remifentanil anesthesia, a small dose of ketamine did not increase the BIS value over the next 15 min.
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Dexmedetomidine (DEX) has analgesic, anxiolytic, and antidelirium effects, and causes little respiratory depression. Behavioral disturbances such as agitation, aggression, and sleep disorder are common in cognitive impairment; this impairment may be one of the risk factors for postoperative delirium. We studied the effects of postoperative DEX administration in elderly patients with cognitive impairment. ⋯ Low-dose DEX is safe and useful for postoperative sedation in elderly patients with cognitive impairment.