European journal of anaesthesiology. Supplement
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Eur J Anaesthesiol Suppl · Sep 1995
Comparative Study Clinical TrialDose-response and time-course of effect of rocuronium bromide in paediatric patients.
We determined dose-response curves and spontaneous recovery of neuromuscular function following a single ED95 dose of rocuronium in 10 infants (1-11 months old), 20 children (2-12 years old) and 20 adults (20-40 years old) during nitrous oxide-oxygen-thiopentone-alfentanil anaesthesia. Neuromuscular block was recorded as adductor pollicis EMG following a supramaximal train-of-four ulnar nerve stimuli at 10 s intervals. ⋯ Time-course of recovery from an average 94% neuromuscular block was similar in all age groups with a 25-75% recovery time of 6.5 +/- 1.8, 5.7 +/- 1.8 and 6.7 +/- 1.6 min in infants, children and adults, respectively. Thus, rocuronium is an intermediate-acting muscle relaxant in all age groups.
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Eur J Anaesthesiol Suppl · Sep 1995
Clinical Trial Controlled Clinical TrialRocuronium bromide in the ICU: dose finding and pharmacokinetics.
Thirty patients requiring elective ventilation in the ICU received either intermittent boluses (25 patients) or a continuous infusion (five patients) of rocuronium. Degree of block was monitored by train-of-four stimuli and maintained at one twitch either observed or palpated. ⋯ Control of ventilation was better with the continuous infusion of rocuronium, but these patients also had a more intense block receiving 9.9 +/- 1.3 micrograms kg-1 min-1 as compared to 6.4 +/- 2.3 micrograms kg-1 min-1 in the bolus group. Elimination half-time, volume of distribution at steady-state, and mean residence time were significantly greater than in surgical patients receiving comparable infusions, but plasma clearance was similar.
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Eur J Anaesthesiol Suppl · Sep 1995
Clinical Trial Controlled Clinical TrialRocuronium with alfentanil and propofol allows intubation within 45 seconds.
Following induction with alfentanil (20 micrograms kg-1) and propofol (2.0-2.5 mg kg-1), four groups of patients were given rocuronium to determine conditions for rapid sequence intubation. Two groups received 0.9 mg kg-1 and two groups received 0.6 mg kg-1. ⋯ Intubating conditions were scored on a four point scale but all were rated as excellent or good. Almost all intubating conditions were excellent in the 0.9 mg kg-1 groups.