European journal of anaesthesiology. Supplement
-
Eur J Anaesthesiol Suppl · Jan 2003
ReviewClinical pharmacology and rationale of analgesic combinations.
Oral fixed drug combination analgesics have potential advantages over monotherapy, but these can only be attained through careful design. ⋯ In summary, combination analgesics can play a valuable role in pain management. However, dubious combinations (directed against the same targets or with unwanted interactions) and 'old fashioned' fixed-dose multiple analgesic agent combinations should be avoided. Fixed-dose combination analgesics are of value only when they have been developed according to rational pharmacokinetic and pharmacodynamic criteria, and when claims for their benefits have been supported by evidence-based data and well-designed clinical studies.
-
Combinations of analgesic drugs provide the opportunity for better efficacy with less overall morbidity than provided by single analgesic agents. This article discusses the rationale, efficacy and safety for a novel analgesic combination: tramadol and acetaminophen (paracetamol). ⋯ Tramadol/acetaminophen combination is a new preparation that is effective in acute or chronic moderate-to-moderately severe pain. It benefits from the complementary actions of the constituent analgesics, having the rapid onset of acetaminophen and the sustained effect of tramadol. The analgesic efficacy of this combination is comparable to that of positive controls, and its adverse event profile is in line with that of its single components.
-
Eur J Anaesthesiol Suppl · Jan 2003
Euroanaesthesia 2003. Abstracts of the joint meeting of the European Society of Anaesthesiologists and European Academy of Anaesthesiology, Confederation of European National Societies of Anaesthesiology, and Association of Anaesthetists of Great Britain & Ireland. May 31-June 3, 2003. Glasgow, Scotland.