Acta anaesthesiologica Belgica
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Acta Anaesthesiol Belg · Jan 1976
Comparative StudyCardiovascular effects of different anesthetics in man. Study of two volatile anesthetics: enflurane (ethrane), halothane (fluothane).
In the first part of this paper we report the effects of 4 short acting intravenous anesthetics (althesin, etomidate, epontol, brietal) on the cardiovascular effects due to ethrane. In the second part we learn with the same induction anesthetic (etomidate) the cardiovascular effects of ethrane and fluothane. We have proved that: 1 degree althesin least potentiates the variations in the cardiovascular parameters under the action of ethrane, 2 degrees halothane 2% decreases more the blood pressure than ethrane 1%.
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Acta Anaesthesiol Belg · Jan 1976
Comparative StudyCardiovascular effects of various anesthetics in man. Four short-acting intravenous anesthetics: althesin, etomidate, methohexital and propanidid.
Four groups of 15 patients without any cardiovascular or pulmonary pathology received an intravenous injection of one of the 4 studied anesthetics, Althesin (0.07 ml/kg), Methohexital (1.6 mg/kg), Etomidate 0.15 mg/kg) or Propanidid (6 mg/kg). Arterial pressure, heart rate, stroke volume and cardiac output were measured every thirty or sixty seconds. ⋯ Arterial pressures did not vary. Under the conditions of the present study and at the dose levels mentioned, Etomidate produced the least changes in cardiac parameters.
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Etomidate 0.2 mg/kg was used as an intravenous hypnotic to induce anesthesia in 198 children. If proved to be a safe and effective agent, with no appreciable side-effects on the cardiovascular or respiratory systems. The main problems in use were a high incidence (27%) of pain after injection, and a 10% incidence of significant myoclonia. In addition, 0.2 mg/kg was assessed as an inadequate induction dose of etomidate in unpremedicated children.
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Uterine blood loss was measured in women undergoing therapeutic abortion during the first trimester of pregnancy. A first group, operated under paracervical block anesthesia, had a mean blood loss of 17 ml. The second group, anesthetized with pentothal, nitrous oxide and enflurane 1%, had a mean loss of 41 ml. The difference is statistically highly significant, but absolute blood losses remained small in both groups.