Acta anaesthesiologica Belgica
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Acta Anaesthesiol Belg · Jan 1995
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialEfficacy and safety of oral tramadol and pentazocine for postoperative pain following prolapsed intervertebral disc repair.
In this multicenter double-blind randomized study the analgesic efficacy and safety of 50 mg tramadol was compared against 50 mg pentazocine by mouth in the treatment of 160 patients with acute pain following prolapsed intervertebral disc repair. The day of surgery patients were treated with parenteral opioids. The study started the morning after surgery. ⋯ Results showed both treatments provided equivalent effective analgesia for the six hours observation period. The global assessment of analgesia by patient and observer was not significantly different for both treatments, although less additional medication was required in the pentazocine group. Side effects were quite common in both groups, and occurred more frequently in the pentazocine group.
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Acta Anaesthesiol Belg · Jan 1995
Randomized Controlled Trial Clinical TrialEvaluation of methylnaltrexone for the reduction of postoperative vomiting and nausea incidences.
We examined the effect of methylnaltrexone on the incidence of postoperative nausea and vomiting in a prospective double-blind placebo controlled study. One hundred and twenty female patients undergoing laparoscopic major gynecological surgery were allocated randomly to receive either 20 mg methylnaltrexone or placebo IV at the end of surgery. ⋯ The corresponding values for the methylnaltrexone group were 20 and 10 percent. We conclude that methylnaltrexone did not prevent nor significantly reduced the incidence and severity of postoperative nausea and vomiting following a balanced anesthetic technique in gynecological procedures.
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Acta Anaesthesiol Belg · Jan 1995
Randomized Controlled Trial Clinical TrialInfluence of sufentanil on propofol anesthesia using a target controlled infusion system.
We assessed the effect of three different dosings of sufentanil on induction, maintenance and recovery characteristics of a propofol target controlled infusion anesthesia in twenty-four patients scheduled for laparoscopic cholecystectomy. The patients were allocated randomly to receive a sufentanil bolus of 15, 30 or 45 micrograms followed by a continuous infusion of sufentanil of 15, 30 or 45 micrograms/h respectively. The maintenance propofol anesthesia was titrated to achieve hemodynamic stability. ⋯ A threefold increase of sufentanil dosing did not significantly affect the induction times nor recovery times following propofol anesthesia. The recovery parameters were determined by the total amount of propofol administered. The mean predicted propofol blood concentrations measured at induction, during maintenance and recovery (opening of eyes) were 3.4-3.9 micrograms/ml, 4.0-4.8 micrograms/ml and 1.1-1.4 micrograms/ml respectively and were not significantly influenced by the sufentanil dosing.
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Acta Anaesthesiol Belg · Jan 1995
Multicenter Study Comparative StudyPerformance of the anesthesiologists in 12 Departments of Anesthesia in Greece.
To assess the performance of anesthesiologists in 12 Departments of Anesthesia a questionnaire was completed by 132 anesthesiologists. The questionnaire included preoperative visit, preoxygenation, the anaesthetic record, time of stay in the operating room, management of apnea at the end of surgery and rapid sequence induction. Anesthesiologists were also asked if they keep update and how. ⋯ To induce anesthesia in patients with full stomach, 89% give thiopentone and succinylcholine, 4% thiopentone and nondepolarizing relaxant, 76% apply cricoid pressure and 5% inflate the lungs via a face mask, (P < 0.0001, P = 0.018 and P < 0.0001 respectively). Eighty-seven percent of the anesthesiologists keep update attending congresses, 76% departmental meetings (P = 0.0015 within the 12 Hospitals), 86% reading journals and 78% reading textbooks. The 12 Departments of Anesthesia presented a uniformity in updating knowledge but not in practicing anesthesia.
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Acta Anaesthesiol Belg · Jan 1995
Randomized Controlled Trial Clinical TrialMivacurium chloride for short laparoscopic procedures.
We have studied the effects of mivacurium after induction of anesthesia with fentanyl-propofol in healthy adult women. Anesthesia was maintained with nitrous oxide in oxygen and continuous infusion of propofol (6-10 mg/kg/hr.). A myorelaxograph (Datex NMT 100) measuring the responses of the adductor pollicis to Train of Four (TOF) stimulations of the ulnar nerve was installed after induction. ⋯ There is no effect of the different bolus dosages on vital signs. We conclude that a bolus dosage of 0.19 mg/kg after induction of anesthesia with fentanyl-propofol offers the best choice when a rapid sequence of induction is required. Mivacurium could be an interesting muscle relaxant in one-day surgery even if a risk of prolonged curarization exists due to its degradation by plasma cholinesterases.