Middle East journal of anaesthesiology
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Middle East J Anaesthesiol · Oct 2015
Randomized Controlled Trial Comparative Study"ANESTHETIC SPARING EFFECT OF INTRAOPERATIVE LIGNOCAINE OR DEXMEDETOMIDINE INFUSION ON SEVOFLURANE DURING GENERAL ANESTHESIA".
Lidocaine and Dexmedetomidine are known to blunt the stress response to surgery, and have anesthetic sparing activity. This study was designed to evaluate and compare the anesthetic sparing effect of intravenous lidocaine with Dexmedetomidine infusion during sevoflurane based general anesthesia and also to assess their effects on hemodynamic parameters. ⋯ Both drugs produce significant anesthetic sparing effect during sevoflurane based general anesthesia, but dexmedetomidine has better sparing effect than lignocaine.