Middle East journal of anaesthesiology
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Middle East J Anaesthesiol · Oct 1988
Ketamine hydrochloride as sole anesthetic for open liver biopsy.
We evaluated the use of ketamine as sole anesthetic agent for open liver biopsy, with particular reference to its effect on liver function and hepatotoxicity and its effect on cardiovascular stability and respiration. From 386 patients who underwent liver biopsy at Jordan University Hospital, 12 had open liver biopsy because of contra-indications for closed needle biopsy. The surgical procedure consisted of a small right paramedian incision allowing inspection of the liver surface and a wedge and needle biopsy. ⋯ Six patients reported dreams, two of which were described as nightmares. There was no liver function decompensation, or significant bilirubin or transaminase elevations in the week following the biopsy. Ketamine is a safe anesthetic to use for open liver biopsy in patients with underlying liver disease, although poor muscle relaxation and nightmares may be significant side effects.
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Middle East J Anaesthesiol · Feb 1988
Randomized Controlled Trial Clinical TrialFailure of lidocaine to modify suxamethonium induced biochemical changes.
Twenty patients were studied in a prospective double-blind randomized trial to determine the effects of intravenous lidocaine pretreatment on suxamethonium induced biochemical changes. Lidocaine 1 mg. kg-1 failed to attenuate changes in serum potassium, significantly decreased serum calcium, and prolonged duration of suxamethonium blockade. There were no significant changes in plasmacholinesterase activity or other biochemical parameters. It is concluded that pretreatment with 1 mg. kg-1 lidocaine failed to attenuate suxamethonium induced biochemical changes.