Revista española de anestesiología y reanimación
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Surgical patients and others admitted to recovery and intensive care units require sedation and pain therapy, for which a range of pharmaceuticals is available. Their use is more or less widespread, but other drugs, such as dexmedetomidine, have been and continue to be studied for application in such patients. Dexmedetomidine, a compound derived from imidazole, has a high affinity for the alpha-2 adrenoreceptor, on which it acts as a potent agonist. ⋯ Moreover, its effect on ventilation is scarce. Dexmedetomidine is presently distributed in the United States but not in the European Union. The aim of this review was to outline the main pharmacological properties of dexmedetomidine, including its pharmacokinetics and pharmacodynamics, to give an overall view of this promising drug.
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Rev Esp Anestesiol Reanim · Aug 2002
Randomized Controlled Trial Clinical Trial[Efficacy of 1% ropivacaine with and without hyaluronidase for peribulbar block].
To determine whether adding hyaluronidase to 1% ropivacaine without adrenalin enhances peribulbar anesthesia for cataract surgery with phacoemulsification. ⋯ The greater efficacy of a peribulbar block with the addition of 10 U/mL of hyaluronidase to 1% ropivacaine without adrenalin, in comparison to 1% ropivacaine alone, was demonstrated by a lower rate of reinjection and ocular mobility, even though no statistically significant difference in either ocular or palpebral akinesia was found.
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Rev Esp Anestesiol Reanim · Aug 2002
[Use of mivacurium chloride during transsternal thymectomy in myasthenic patient].
Myasthenia gravis is an autoimmune disease characterized by the presence of circulating IgG antibodies, which interact with acetylcholine receptors and interfere with neuromuscular transmission. ⋯ The anesthetic effect of mivacurium was twice as great in myasthenic patients, in whom it behaved like an intermediate-level non-depolarizing muscle relaxant. Mivacurium can reduce prolonged mechanical ventilation in patients who are myasthenic or pharmacologically immunosuppressed and at risk of sepsis arising in the respiratory tract.
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Rev Esp Anestesiol Reanim · Aug 2002
[Morbidity and mortality related to anesthesia and surgery in 60 patients treated with bariatric surgery].
To identify the factors predicting morbidity and mortality in patients undergoing bariatric surgery for morbid obesity in our hospital. ⋯ Major complications of bariatric surgery occurred in 18.3% of our patients and mortality was 5%. Physical status was a prognostic factor for both early (24 h) postoperative morbidity and mortality in our morbidly obese patients, whereas BMI was related to morbidity during the first week after surgery.
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Rev Esp Anestesiol Reanim · Aug 2002
[Pulse oximetry reduces the unnecessary administration of oxygen in the postanesthesia recovery period].
To investigate whether patients admitted to the postanesthesia recovery unit (PRU) need routine oxygen supplementation in the immediate postoperative period, by measuring changes in arterial oxygen saturation (SpO2) with a pulse oximeter. ⋯ Our results are sufficient to demonstrate the validity of pulse oximetry for avoiding indiscriminate oxygen supplementation in patients admitted to the PRU.