Revista española de anestesiología y reanimación
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Rev Esp Anestesiol Reanim · Oct 1998
Comparative Study Clinical Trial[Characterization of dose profile of remifentanil with computer simulation: comparative study with fentanyl and alfentanyl].
To estimate the optimum dosing regimen and delivery system for remifentanil, a new opioid, using computer simulations based on information from pharmacokinetic and pharmacodynamic models available for fentanyl, alfentanil and remifentanil, as well as from clinical trials of fentanyl and alfentanil. ⋯ Information from pharmacokinetic and pharmacodynamic models allows us to establish the effect site concentration ranges for remifentanil and determine the ideal administration technique for this drug. The simulation also allows us to compare the properties of remifentanil to those of other common opioids such as fentanyl and alfentanil. The results are fairly consistent with clinical evidence, demonstrating the power of pharmacokinetic and pharmacodynamic models for rationally establishing opioid dosing guidelines.
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Rev Esp Anestesiol Reanim · Aug 1998
[Bibliometric analysis of the original articles published in the Revista Española de Anesthesiología y Renimación in 10 years (1987-1996)].
To describe the original research articles published in Revista Española De Anestesiología y Reanimación (REAR) from 1987 through 1996, as well as to characterize the citations included in those articles. ⋯ The number of authors of original research articles published in REAR in the last 10 years was high. Spanish authors in anesthesiology cite mainly literature in English; use up-to-date sources of information, mainly journals; and take a large proportion of information from a small number of journals, which are those of greatest international impact in our specialty.
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Rev Esp Anestesiol Reanim · Aug 1998
Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial[Comparison of the effect of desflurane with isoflurane in patients over 65 years of age: multicenter study].
To compare the effects of desflurane (DES) and isoflurane (ISO) in patients over 65 years of age based on recovery, hemodynamic variables, need for additional drugs and postoperative rates of nausea and vomiting. ⋯ Patients over 65 years of age anesthetized with DES recovered in half the time of patients anesthetized with ISO. DES is a safe anesthetic for elderly patients and may offer clinical advantages.
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Rev Esp Anestesiol Reanim · Aug 1998
Review[Resuscitation of the burned child in critical condition].
Recent advances in surgical techniques, control of infection and nutritional support have dramatically increased the survival rates of burned children. The characteristics of severely burned pediatric patients dictate that management be different from that required for adults in the intensive care unit. The formulas for fluid replacement should be based on body surface rather than weight in children and adjusted for degree of stress and age, with appropriate monitoring and treatment of hypothermia, pain and associated psychological disorders. Early assessment and treatment of airway obstruction and gas and smoke inhalation syndromes with high FiO2 is necessary; prophylactic endotracheal intubation may be required.
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Rev Esp Anestesiol Reanim · Aug 1998
Case Reports[Epidural hematoma after removal of an epidural catheter].
Epidural hematoma is a rare but serious neurological complication of epidural anesthesia. We report the case of a 61-year-old man with squamous cell carcinoma of the lung who suffered an epidural hematoma after undergoing right double lobectomy. Before anesthetic induction an epidural catheter was inserted to the D5-D6 space for postoperative analgesia. ⋯ Neurologic symptoms improved in the following hours and additional surgery was not required. The patient was released without neurological symptoms 10 days after lung surgery. We discuss the prevalence, etiology and treatment of epidural hematoma related to epidural anesthesia.