Journal of the Medical Association of Thailand = Chotmaihet thangphaet
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Clinical Trial
Management of cancer-related pain with transdermal fentanyl.
This study demonstrates that TTS-fentanyl can provide sufficient pain relief in cancer patients equivalent to that achieved with morphine with additional benefits of convenience and reduced side effects.
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Clinical Trial
Hyperthermia conjunction with radiation therapy in breast cancer with chest wall recurrence: a preliminary report.
1. Hyperthermia is a very effective and valuable tool which produces a high degree of response in chest wall recurrent breast cancer, especially in cases, where curative doses of radiation could not be achieved, due to previous radiation treatment. 2. Hyperthermia once a week is sufficient to produce the enhancement of radiation neither increasing the burden to the patient nor increasing the workload to the department. 3. ⋯ In small satellite nodules, whole chest wall irradiation should be considered to prevent recurrence in the adjacent area. 5. An air cooling system is effective and suitable for an ulcerative lesion. Further randomized study for long term local control and survival should be explored.
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Eighteen preterm infants severely ill with respiratory distress syndrome who required assisted ventilaton were given modified natural surfactant (Survanta) endotracheally. They had a mean +/- SEM gestational age of 31.2 +/- 0.4 weeks (range 28-34) and a mean +/- SEM birthweight of 1562 +/- 71 g (range 1160-2010). Average time of initial surfactant administration was 15 +/- 1.7 hour (range 5-24). ⋯ Four infants expired, two were due to severe asphyxia/shock and two died of unrelated causes. Among the 14 survivors who came for follow-up, two cases of retinopathy of prematurity had gradually regressed, one had cerebral palsy and delayed development. Surfactant rescue therapy is a supplemental beneficial treatment for severe respiratory distress syndrome while newborn intensive care concept is necessary for efficient diagnosis and treatment of RDS.
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Randomized Controlled Trial Clinical Trial
A comparison of serum magnesium sulfate levels in pregnant women with severe preeclampsia between intravenous and intramuscular magnesium sulfate regimens: a randomized controlled trial.
The frequency of blood samples that achieved therapeutic level was lower in the group of maintenance with intravenous regimen than the intramuscular regimen significantly at 15, 30, 60, 120 and 240 minutes after loading dose. The mean level of serum magnesium sulfate in the intravenous group was significantly lower than intramuscular group. This study supported to choose the maintenance by intramuscular regimen. However, further study is required to analyse the effect of higher level of magnesium sulfate in Thai patients.
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Randomized Controlled Trial Clinical Trial
Cost-effectiveness analysis of patient-controlled analgesia, intramuscular q.i.d. injection and p.r.n. injection for postoperative pain relief.
We conclude that the intravenous PCA method is a cost-effective technique. Although the PCA device is expensive, the cost-effectiveness analysis should give explicit figures for physicians and the hospital administrators to decide whether they should use the PCA instead of the conventional method.