AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium
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The Family History Ontology formalizes nursing conceptualization about family and family history. Traditional methods of instance testing were applied to evaluate the completeness of the ontology and demonstrated favorable domain coverage. Testing also revealed a need for a new category of instance test results, "by inference", for data that can be represented through the use of inference rules associated with the ontology rather than requiring direct manual entry.
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AMIA Annu Symp Proc · Nov 2008
Clinical TrialImplementing a computerized pneumococcal vaccination reminder system in an emergency department: a prospective study.
The Emergency Department is a challenging environment to implement a sustainable pneumococcal vaccination program. To increase vaccination rates for patients > or = 65 years old, we prospectively evaluated a closed-loop informatics approach over a 1-year period. Among 3,455 screened patients 1,393 were up-to-date and 2,062 were eligible for the vaccination. 159 (7.7%) patients received the vaccine at the initial visit and an additional 59 (2.9%) at a subsequent visit, resulting in an overall rate increase of 10.6%.
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AMIA Annu Symp Proc · Nov 2008
Comparative StudyComparison of ontology-based semantic-similarity measures.
Semantic-similarity measures quantify concept similarities in a given ontology. Potential applications for these measures include search, data mining, and knowledge discovery in database or decision-support systems that utilize ontologies. To date, there have not been comparisons of the different semantic-similarity approaches on a single ontology. ⋯ We found that there was poor agreement among those metrics based on information content with the ontology only metric. The metric based only on the ontology structure correlated most with expert opinion. Our results suggest that metrics based on the ontology only may be preferable to information-content-based metrics, and point to the need for more research on validating the different approaches.
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AMIA Annu Symp Proc · Nov 2008
Supporting the design of translational clinical studies through the generation and verification of conceptual knowledge-anchored hypotheses.
The ability to generate hypotheses based upon the contents of large-scale, heterogeneous data sets is critical to the design of translational clinical studies. In previous reports, we have described the application of a conceptual knowledge engineering technique, known as constructive induction (CI) in order to satisfy such needs. ⋯ Our report will be framed in the context of an ongoing project to generate hypotheses related to the contents of a translational research data repository maintained by the CLL Research Consortium. Such hypotheses will are intended to inform the design of prospective clinical studies that can elucidate the relationships that may exist between biomarkers and patient phenotypes.
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AMIA Annu Symp Proc · Nov 2008
Application of statistical process control methods to monitor guideline adherence: a case study.
Control charts are tools from the field of statistical process control for visualizing the longitudinal development of quality indicators, and detecting whether the underlying process is changing. They have been used in critical care and disease management settings to monitor and improve patient outcomes. This paper investigates the application of control charts to monitor adherence to clinical practice guidelines by healthcare professionals. ⋯ Guideline adherence increased in clinics that started using decision support. A gradual drop in adherence was seen in clinics that continued using decision support over a longer period. Control charts are more sensitive to detect changes in adherence than summary comparisons in before-after designs.