Danish medical journal
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The use of designated emergency teams for cardiac arrest and trauma patients is widely implemented. However, the use of designated teams in Danish emergency departments (EDs) has not been investigated. Our aim was to investigate the use and staffing of emergency teams in Danish EDs. ⋯ Designated teams for patients in cardiac arrest and trauma patients are available in all Danish EDs. More senior staff form part of trauma teams than cardiac arrest teams. There is limited access to designated teams caring for critically ill medical patients in Danish EDs.
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Danish medical journal · Jun 2012
Most patients regain prefracture basic mobility after hip fracture surgery in a fast-track programme.
Treatment of patients with hip fracture has improved over the past decade. Still, some patients do not regain independent mobility within their primary hospital stay even if they follow a multimodal fast-track surgical programme. The aim of the present article was to examine the validity of the preliminary prefracture New Mobility Score (NMS), age and fracture type as independent predictors of in-hospital outcome after hip fracture surgery. ⋯ Prefracture NMS, age and fracture type were confirmed as independent predictors of in-hospital outcome in patients with hip fracture who followed a multimodal rehabilitation concept.
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Danish medical journal · Jun 2012
Catheter-based renal denervation for treatment of resistant hypertension.
Activation of renal sympathetic nerves is associated with the development of hypertension. Catheter-based renal sympathetic denervation with radiofrequency energy ablation is a new promising treatment option for resistant hypertension. We here report the first Danish experiences and results with this technique. ⋯ Catheter-based renal sympathetic denervation is a feasible and in several cases also effective treatment option for patients with resistant hypertension. Adequately designed controlled trials are needed to assess the long-term safety and the full potential of this treatment.
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The overall aim of the PhD project was to elucidate the association of human longevity with genetic variation in major candidate genes and pathways of longevity. Based on a thorough literature and database search we chose to apply a pathway approach; to explore variation in genes composing the DNA damage signaling, DNA repair, GH/IGF-1/insulin signaling and pro-/antioxidant pathways. In addition, 16 genes which did not belong to the core of either pathway, however recurrently regarded as candidate genes of longevity (e.g. ⋯ Our studies verified a role of TERC in human telomere length and of FOXO3A in human longevity (survival from middle age to old age), while a novel role of TERC in human longevity was found. Finally, in addition to the literature and database searches, the genotype data generation and the data analyses mentioned here, RNA purification and qPCR experiments have been initiated in order to investigate gene expression of some of the genes holding SNPs found to be associated with human longevity. Data on one of these genes (IL6) have been included in a manuscript.
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Standard treatment of critically ill patients undergoing mechanical ventilation is continuous sedation. This standard treatment to all patients has been greatly challenged over the last decade. At the general intensive care department at Odense University hospital the standard treatment has been no sedation. The general impression has been that this reduces time in mechanical ventilation and reduces complications such as acute renal failure. It has not been the impression that this treatment increased the risk of long term psychological problems compared to standard treatment with sedation. The "no-sedation" method has however never been described in the literature or tested in a prospective randomized trial. ⋯ A strategy of no sedation to critically ill patients undergoing mechanical ventilation resulted in fewer days in mechanical ventilation, shorter ICU and hospital length of stay compared to a standard strategy with sedation. Also the risk of acute renal impairment seems to be reduced with the use of no sedation. The no sedation strategy does not seem to alter long term psychological outcome.