Anesteziologiia i reanimatologiia
-
Anesteziol Reanimatol · Nov 2002
[Permeability of the blood-brain barrier in severe craniocerebral trauma].
Permeability of the blood-brain barrier was studied by comparing the molar concentrations of albumin and alpha 2-macroglobulin in the spinal fluid and blood of patients with severe brain injury. If the outcome was good, the selective permeability of the barrier was shown to be fully retained, which meant that its regulatory and protective functions remained normal. If the outcome was poor, the selective permeability changed to a greater extent and the alterations found suggested that the regulatory function of the barrier was preserved with simultaneous loss of its protective properties. More marked changes in the function of blood-brain barrier and in the protein composition of spinal fluid occurred with simultaneously elevated intracranial pressure.
-
Anesteziol Reanimatol · Sep 2002
Comparative Study[Anesthesiological aspects of early activation of patients after aortocoronary bypass surgery].
The specific features of the course of anesthesia and the time of extubation were studied in 142 patients suffering from coronary heart disease who had undergone myocardial revascularization. All the patients were divided into 3 groups in accordance with the type of anesthesia. Group 1 patients (n = 48) received routine anesthesia with ketamine, benzodiazepines, and large-dose fentanyl. ⋯ The developed anesthesiological protocol based on thoracic epidural anesthesia enables extubation to be carried out on the operating table within an hour in 75% of patients after aortocoronary bypass surgery. A comparative intraoperative analysis of hemodynamics, the incidence of myocardial ischemia, arrhythmias, glucose levels has indicated that the anesthesia techniques aimed at a patient's early activation are not inferior in the degree of protection to routine anesthesia using large doses of opioids, ketamine, and diazepam. When used in combination with thoracic epidural block, the methods are superior to the latter.
-
Anesthesiological aids were analyzed in 70 obese patients undergone a total of 88 surgical interventions (in 1992 to 2002). This category of patients presented difficulties with tracheal intubation and gas exchange management at all stages of anesthesia and medication, which is associated with high chest rigidity, large distribution volume due to excess fatty tissue and serious comorbidity. The authors propose basic ways of solving the problems occurring with the use of fibrooptic equipment for tracheal intubation and suggest that short-acting agents with extraorgan elimination for induction and maintenance of anesthesia and special methods of artificial pulmonary ventilation (traditional volume-cyclic and jetwise high-frequency pulmonary ventilation) should be used to maintain effective gas exchange.
-
Anesteziol Reanimatol · Sep 2002
[Rocuronium (esmerone) in anesthesia during surgery under extracorporeal circulation].
The study was undertaken to examine the myoplegic, hemodynamic, and histamine-releasing effects of the new aminosteroidal myorelaxant Rocuronium (esmerone, Organon firm) used to maintain anesthesia in cardiac surgical patients by orienting to early tracheal extubation. Twenty two patients aged 50 +/- 3 years operated on under extracorporeal circulation were examined. At the initial stage of maintenance, the agent in a dose of 0.6 mg/kg failed to affect cardiac pump function and to elevate plasma histamine levels. ⋯ Early tracheal extubation was conducted in 68% of the patients 69 +/- 7.6 min after the end of the operation. Residual myoplegia was absent. The predictable recovery of NMC following the use of Rocuronium creates conditions for early activation of patients operated on under extracorporeal circulation.
-
Anesteziol Reanimatol · Sep 2002
Comparative Study[Modern nondepolarizing myorelaxants in cardiac surgery].
The electromyographic and hemodynamic profile and side effects of the new nondepolarizing myorelaxants Mivacurium chloride (Mivacron), Cisathracurium besilate (Nimbex), Rocuronium bromide (Esmerone) were studied in 117 adult patients. All the test myorelaxants as bolus or infusion in a dose of 3. ED95 were found to be effective in creating adequate conditions for tracheal intubation and neuromuscular block (NMB) maintenance during operations on the coronary arteries and cardiac vales under extracorporeal circulation. ⋯ The former was found to have a slight vagolytic effect. When rapidly injected as bolus, Mivacron caused a significant decrease in blood pressure and heart rate by 10-12%. Based on a comprehensive study, the authors have scientifically substantiated principles in the choice of nondepolarizing myorelaxants in cardiac surgical patients in relation to the baseline hemodynamic values, the stage of an operation, and the duration of artificial pulmonary ventilation.