Anesteziologiia i reanimatologiia
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Anesteziol Reanimatol · Jul 2013
[Influence of cerebral perfusion pressure and cardiac output on brain oxygenation and metabolism].
The article contains results of examination of correlation between systemic hemodynamic and brain oxygenation and metabolism in patients with intracranial hemorrhage. Cardiac index (CI) and cerebral perfusion pressure (CPP) levels were compared to brain oxygenation and metabolism in 8 patients with intracranial hemorrhage (137 measurements). CI alterations didn't influence on PbrO2, glucose level or lactate/pyruvate ratio in the brain interstitial fluid in patients with traumatic brain injury. ⋯ CPP elevation led to PbrO2 increasing in patients with subarachnoid hemorrhage due to aneurism rupture. This phenomenon can be explained by damage mechanisms of cerebral blood flow autoregulation. In these cases CI elevation was accompanied by worsening of aerobic metabolism in theoretically intact regions and improving it in injured brain regions.
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Anesteziol Reanimatol · Jul 2013
[Morphological changes in the lumbar dorsal root ganglion of the domestic porcine after pulsed radiofrequency stimulation].
Pulsed radiofrequency (PRF) is a percutaneous minimal invasive procedure that can be used when conservative pain therapy methods have been ineffective. The effectiveness of PRF was demonstrated in various good quality randomized control studies, but mechanisms of action are still unclear. The aim of our study is to analyse the histological effects of PRF on the domestic porcine dorsal root ganglion (DRG), and evaluate the expression of biomarkers in gangliocytes. 3 domestic porcines were investigated. ⋯ PRF in spinal gangliocytes of lumbar region increases neural tissue cytoskeleton factors like NF and GFAP suggesting about active regeneration processes into the cells 1 month after the procedure. Spinal gangliocytes one month after PRF treatment notably increases Hsp-70 expression suggesting about activation of cellular activity and inhibitory role reducing of oxidative stress. Similar number of apoptotic cells in spinal ganglia of lumbar region after PRF and control side suggests about inhibitory role of PRF on programmed cell death and stimulation of cell survival.
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Anesteziol Reanimatol · May 2013
[SCD14-ST (presepsin) level monitoring in cardiac surgical patients during perioperative period].
Purpose of the study was to define prognostic ability of presepsin (sCD14-ST) as a predictor of complications in cardiac surgical patients during perioperative period. ⋯ sCD14-ST monitoring with the use of severity-of-disease scales and recent biomarkers allow to identify patients with high risk of infection complications and untoward outcomes.
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Anesteziol Reanimatol · May 2013
[Prediction of postoperative pain on the basis of the psychological characteristics of patients and standard pain stimuli].
Practical physicians do not have instruments for objective pain assessment despite recent advances of neurophysiology and pain pharmacology. The article deals with the study of relations between preoperative pain sensitivity (finger prick and venipuncture) and pain level after surgery. 60 patients involved in the study were divided into two groups. Pain sensitivity was assessed in all patients by visual analogue scale before surgery, after awaking, in 1 hour and in 3 hours after awaking and in 1 day after the surgery. ⋯ All patients were assessed by 70 criteria (54 psychological). Results of the study show that postoperative pain syndrome is affected by different psychophysiological factors. Therefore it is difficult to forecast the level of postoperative pain syndrome.
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Anesteziol Reanimatol · May 2013
Randomized Controlled Trial[Application of hyperosmotic iso-oncotic solutions for prolonged veno-venous haemofiltration in patients with gramm negative sepsis].
Dynamics of circulation and elimination of low and medium molecular weight substances and lipopolysaccharides of Gramm negative bacteria were studied during prolonged veno-venous haemofiltration in patients with Gramm negative sepsis. Positive effect of HyperHAES solution for endotoxicosis compensation has been defined in the study. HyperHAES can be used repeatedly during prolonged veno-venous haemofiltration.