Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
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Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi · Sep 2008
[Phosphoinositide 3-kinase/Akt pathway involved in regulation of hypoxia inducible factor 1alpha in hypoxia ischemia brain damage of neonatal rats].
To investigate the expression of hypoxia inducible factor 1alpha (HIF-1alpha) protein and the activation of phosphoinositide 3-kinase/Akt (PI3K/Akt) signaling pathway in neurons under hypoxia ischemia condition, and to elucidate the role of PI3K/Akt on HIF-1alpha regulation in the developing neurons after hypoxia ischemia brain damage (HIBD). ⋯ These results suggested that the HIBD of neonatal rats may activate PI3K/Akt signaling pathway and further induce the expression of HIF-1alpha, indicating PI3K/Akt signaling pathway and HIF-1alpha could be a potential target for treatment of neonatal HIBD.
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Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi · Sep 2008
[Time limit of repairing old sciatic nerve defect in rats].
To investigate the time limit of repairing old sciatic nerve defect in rats and observe the repair effect of autogenous nerve transplantation on old sciatic nerve defect in rats. ⋯ Autogenous nerve transplantation is capable of repairing 1- and 3-month sciatic nerve defect to some degree in rat, but repair effect is not obvious on 6-month sciatic nerve defect in rats.