World journal of gastroenterology : WJG
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World J. Gastroenterol. · Dec 2014
2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-β1 signaling.
To investigate whether targeting proteasome might reverse intestinal fibrosis in rats. ⋯ Rats with TNBS-induced chronic colitis exhibited colon fibrosis associated with higher TGF-β signaling. Proteasome inhibition by bortezomib had no effect on fibrosis in our experimental conditions.
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World J. Gastroenterol. · Dec 2014
Review Meta AnalysisReduced incidence and mortality from colorectal cancer with flexible-sigmoidoscopy screening: a meta-analysis.
To conduct a systematic review and meta-analysis of published population-based randomized controlled trials (RCTs). ⋯ This meta-analysis suggests that screening FS can reduce the incidence of proximal and distal CRC and mortality from distal CRC along with reduction in diagnosis of advanced CRC.
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Acute pancreatitis remains a clinical challenge, despite an exponential increase in our knowledge of its complex pathophysiological changes. Early fluid therapy is the cornerstone of treatment and is universally recommended; however, there is a lack of consensus regarding the type, rate, amount and end points of fluid replacement. ⋯ The basic goal of fluid epletion should be to prevent or minimize the systemic response to inflammatory markers. For this review, various studies and reviews were critically evaluated, along with authors' recommendations, for predicted severe or severe pancreatitis based on the available evidence.
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World J. Gastroenterol. · Dec 2014
Modified laparoscopic splenectomy and azygoportal disconnection combined with cell salvage is feasible and might reduce the need for blood transfusion.
To investigate perioperative outcomes in patients undergoing modified laparoscopic splenectomy and azygoportal disconnection (MLSD) with intraoperative autologous cell salvage. ⋯ Intraoperative cell salvage during MLSD is feasible and safe and may become the gold standard for liver cirrhosis with portal hypertensive bleeding and hypersplenism.
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World J. Gastroenterol. · Dec 2014
Comparative StudyPrognosis of ulcerative colitis differs between patients with complete and partial mucosal healing, which can be predicted from the platelet count.
To determine the difference in clinical outcome between ulcerative colitis (UC) patients with Mayo endoscopic subscore (MES) 0 and those with MES 1. ⋯ The relapse rate differed greatly between patients with complete and partial mucosal healing. A shift from complete to partial healing in clinically stable UC patients can be predicted by monitoring PLT.