World journal of gastroenterology : WJG
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World J. Gastroenterol. · Nov 2013
Predictors of Clostridium difficile infection severity in patients hospitalised in medical intensive care.
To describe and analyse factors associated with Clostridium difficile infection (CDI) severity in hospitalised medical intensive care unit patients. ⋯ We report predictors of severe CDI not dependent on time of assessment. Such factors could help in the development of a quantitative score in ICU's patients.
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World J. Gastroenterol. · Nov 2013
Shugan-decoction relieves visceral hyperalgesia and reduces TRPV1 and SP colon expression.
To evaluate the therapeutic effect of Shugan-decoction (SGD) on visceral hyperalgesia and colon gene expressions using a rat model. ⋯ Shugan-decoction can reduce chronic stress-induced visceral hypersensitivity in rats, and the regulatory mechanism may involve mediating the expressions of TRPV1 and SP in colon tissues.
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World J. Gastroenterol. · Nov 2013
ReviewClostridium difficile and inflammatory bowel disease: role in pathogenesis and implications in treatment.
Clostridium difficile (C. difficile) is the leading cause of antibiotic associated colitis and nosocomial diarrhea. Patients with inflammatory bowel disease (IBD) are at increased risk of developing C. difficile infection (CDI), have worse outcomes of CDI-including higher rates of colectomy and death, and experience higher rates of recurrence. However, it is still not clear whether C. difficile is a cause of IBD or a consequence of the inflammatory state in the intestinal environment. ⋯ Antibiotic therapy with either oral metronidazole, vancomycin, or the novel antibiotic-fidaxomicin, should be initiated as soon as possible. Fecal macrobiota transplantation constitutes another optional treatment for severe/recurrent CDI. The aim of this paper is to review recent data on CDI in IBD: role in pathogenesis, diagnostic methods, optional treatments, and outcomes of these patients.
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World J. Gastroenterol. · Nov 2013
Comparative StudySingle-incision vs three-incision laparoscopic cholecystectomy for complicated and uncomplicated acute cholecystitis.
To compare the clinical outcome of single-incision laparoscopic cholecystectomy (SILC) and three-incision laparoscopic cholecystectomy (3ILC) for acute cholecystitis. ⋯ SILC is safe and efficacious for patients with acute cholecystitis. The main benefit is a faster recovery than that achieved with 3ILC.