World journal of gastroenterology : WJG
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World J. Gastroenterol. · Jul 2013
Therapeutic efficacy of baclofen in refractory gastroesophageal reflux-induced chronic cough.
To evaluate the efficacy and safety of baclofen for treatment of refractory gastroesophageal reflux-induced chronic cough (GERC) unresponsive to standard anti-reflux therapy. ⋯ Baclofen is a useful, but suboptimal treatment option for refractory GERC.
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World J. Gastroenterol. · Jul 2013
Effects of rhein on intestinal epithelial tight junction in IgA nephropathy.
To investigate the effects of rhein on intestinal epithelial tight junction proteins in rats with IgA nephropathy (IgAN). ⋯ Rhein can enhance the expression of ZO-1 and occludin, repair damaged tight junctions, and protect the intestinal barrier.
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World J. Gastroenterol. · Jul 2013
ReviewTreatment options of inflammatory appendiceal masses in adults.
At present, the treatment of choice for uncomplicated acute appendicitis in adults continues to be surgical. The inflammation in acute appendicitis may sometimes be enclosed by the patient's own defense mechanisms, by the formation of an inflammatory phlegmon or a circumscribed abscess. The management of these patients is controversial. ⋯ The need for interval appendectomy after successful nonsurgical treatment has recently been questioned because the risk of recurrence is relatively small. After successful nonsurgical treatment of an appendiceal mass, the true diagnosis is uncertain in some cases and an underlying diagnosis of cancer or Crohn's disease may be delayed. This report aims at reviewing the treatment options of patients with enclosed appendiceal inflammation, with emphasis on the success rate of nonsurgical treatment, the need for drainage of abscesses, the risk of undetected serious disease, and the need for interval appendectomy to prevent recurrence.
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World J. Gastroenterol. · Jul 2013
Clinical significance of melatonin concentrations in predicting the severity of acute pancreatitis.
To assess the value of plasma melatonin in predicting acute pancreatitis when combined with the acute physiology and chronic health evaluation II (APACHEII) and bedside index for severity in acute pancreatitis (BISAP) scoring systems. ⋯ The melatonin concentration is closely related to the severity of AP and the BISAP score. Therefore, we can evaluate the severity of disease by measuring the levels of serum melatonin.
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World J. Gastroenterol. · Jul 2013
Polydatin attenuated food allergy via store-operated calcium channels in mast cell.
To investigate the effect of polydatin (PD), a resveratrol glucoside, on mast cell degranulation and anti-allergic activity. ⋯ Taken together, our data indicate that PD stabilizes mast cells by suppressing intracellular Ca(2+) mobilization, mainly through inhibiting Ca(2+) entry via SOCs, thus exerting a protective role against OVA-sensitized food allergy.