World journal of gastroenterology : WJG
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World J. Gastroenterol. · Oct 2012
Protection of ghrelin postconditioning on hypoxia/reoxygenation in gastric epithelial cells.
To investigate the protective effect and mechanisms of ghrelin postconditioning against hypoxia/reoxygenation (H/R)-induced injury in human gastric epithelial cells. ⋯ Ghrelin postconditioning protected against H/R-induced injury in human gastric epithelial cells, which indicated that this protection might be associated with GHS-R, VR1 and the PI3K/Akt signaling pathway.
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World J. Gastroenterol. · Oct 2012
Editorial ReviewCell sheet technology for regeneration of esophageal mucosa.
The progress of tissue-engineering technology has realized development of new therapies to treat various disorders by using cultured cells. Cell- and tissue-based therapies have been successfully applied to human patients, and several tissue-engineered products have been approved by the regulatory agencies and are commercially available. In the review article, we describe our experience of development and clinical application of cell sheet-based regenerative medicine. ⋯ We performed a preclinical study with a canine model. In human clinical settings, cell culture and cell sheet fabrication were performed in clean rooms according to good manufacturing practice guidelines, and pharmaceutical drugs were used as supplements to culture medium in place of research regents used in animal study. We believe that cell-based regenerative medicine would be useful to improve quality of life of patients after EMR or ESD.
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World J. Gastroenterol. · Oct 2012
Comparative StudyVolumetric-modulated arc therapy vs. c-IMRT in esophageal cancer: a treatment planning comparison.
To compare the volumetric-modulated arc therapy (VMAT) plans with conventional sliding window intensity-modulated radiotherapy (c-IMRT) plans in esophageal cancer (EC). ⋯ Compared with c-IMRT, VMAT, especially the 2A, slightly improves the OAR dose sparing, such as lungs and heart, and reduces NTCP and MU with a better PTV coverage.
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World J. Gastroenterol. · Oct 2012
Case ReportsAn endoluminal aortic prosthesis infection presenting as pneumoaorta and aortoduodenal fistula.
Herein, we present a case of pneumoaorta and aortoduodenal fistula (ADF) caused by an endoluminal aortic prosthesis infection. An 82-year-old man underwent endovascular aneurysm repair with a stent graft to exclude a 5.1-cm abdominal aortic aneurysm. Three months after the index procedure, the patient was taken to the emergency department at a medical university hospital. ⋯ The patient died of septic shock despite emergency surgery and intensive care. When encountered, stent graft infections require appropriate antibiotics and graft explantation. The diagnosis of an ADF is important, and surgery remains the most effective management if septic shock presents despite conservative treatment.
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World J. Gastroenterol. · Oct 2012
Inhalation of hydrogen gas reduces liver injury during major hepatotectomy in swine.
To study the effect of H2 gas on liver injury in massive hepatectomy using the intermittent Pringle maneuver in swine. ⋯ H2 gas attenuates markedly ischemia and portal hyperperfusion injury in pigs with massive hepatotectomy, possibly by the reduction of inflammation and oxidative stress, maybe a potential agent for treatment in clinic.