World journal of gastroenterology : WJG
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World J. Gastroenterol. · Jan 2018
ReviewSystematic review of colorectal cancer screening guidelines for average-risk adults: Summarizing the current global recommendations.
To summarize and compare worldwide colorectal cancer (CRC) screening recommendations in order to identify similarities and disparities. ⋯ Average risk individuals between 50 and 75 years should undergo CRC screening. Recommendations for optimal surveillance intervals, preferred tests/test cascade as well as the optimal timing when to start and stop screening differ regionally and should be considered for clinical decision making. Furthermore, local resource availability and patient preferences are important to increase CRC screening uptake, as any screening is better than none.
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World J. Gastroenterol. · Dec 2017
Human small intestine is capable of restoring barrier function after short ischemic periods.
To assess intestinal barrier function during human intestinal ischemia and reperfusion (IR). ⋯ This study directly correlates histological data with intestinal permeability tests, revealing that the human gut has the ability of to withstand short episodes of ischemia, with morphological and functional recovery of the intestinal barrier within 120 min of reperfusion.
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World J. Gastroenterol. · Dec 2017
ReviewClinical epidemiology and disease burden of nonalcoholic fatty liver disease.
Nonalcoholic fatty liver disease (NAFLD) is defined as the presence of hepatic fat accumulation after the exclusion of other causes of hepatic steatosis, including other causes of liver disease, excessive alcohol consumption, and other conditions that may lead to hepatic steatosis. NAFLD encompasses a broad clinical spectrum ranging from nonalcoholic fatty liver to nonalcoholic steatohepatitis (NASH), advanced fibrosis, cirrhosis, and finally hepatocellular carcinoma (HCC). NAFLD is the most common liver disease in the world and NASH may soon become the most common indication for liver transplantation. ⋯ Based on NAFLD subtypes, it has the potential to progress into advanced fibrosis, end-stage liver disease and HCC. The increasing prevalence of NAFLD with advanced fibrosis, is concerning because patients appear to experience higher liver-related and non-liver-related mortality than the general population. The increased morbidity and mortality, healthcare costs and declining health related quality of life associated with NAFLD makes it a formidable disease, and one that requires more in-depth analysis.
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World J. Gastroenterol. · Dec 2017
Efficacy of noninvasive evaluations in monitoring inflammatory bowel disease activity: A prospective study in China.
To optimize the efficacy of noninvasive evaluations in monitoring the endoscopic activity of inflammatory bowel disease (IBD). ⋯ FC is the most promising noninvasive evaluation for monitoring the endoscopic activity of CICD and UC. CFA might be more accurate for IBD activity evaluation.
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World J. Gastroenterol. · Nov 2017
Review Meta AnalysisShort-term clinical outcomes of laparoscopic vs open rectal excision for rectal cancer: A systematic review and meta-analysis.
To review evidence on the short-term clinical outcomes of laparoscopic (LRR) vs open rectal resection (ORR) for rectal cancer. ⋯ LRR is associated with lesser blood loss, smaller incision length, and longer operative times compared to ORR. No differences are observed for postoperative morbidity and mortality.