World journal of gastroenterology : WJG
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World J. Gastroenterol. · Aug 2014
Review Meta AnalysisTransthoracic vs transhiatal surgery for cancer of the esophagogastric junction: a meta-analysis.
To compare the efficacy and safety of the transthoracic and transhiatal approaches for cancer of the esophagogastric junction. ⋯ The transhiatal approach for cancers of the esophagogastric junction, especially types III, should be recommended, and its long-term outcome benefits should be further evaluated.
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World J. Gastroenterol. · Aug 2014
Comparative StudyIGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions.
To investigate insulin-like growth factor 2 (IGF2) differentially methylated region (DMR)0 hypomethylation in relation to clinicopathological and molecular features in colorectal serrated lesions. ⋯ IGF2 DMR0 hypomethylation may be an infrequent epigenetic alteration in the SSA pathway. Hypomethylation of IGF2 DMR0 and LINE-1 may play a role in TSA pathway progression.
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World J. Gastroenterol. · Aug 2014
Dihydromyricetin inhibits migration and invasion of hepatoma cells through regulation of MMP-9 expression.
To investigate the effects of dihydromyricetin (DHM) on the migration and invasion of human hepatic cancer cells. ⋯ These findings demonstrate that DHM inhibits the migration and invasion of hepatoma cells and may serve as a potential candidate agent for the prevention of HCC metastasis.
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World J. Gastroenterol. · Jul 2014
ReviewCachexia and pancreatic cancer: are there treatment options?
Cachexia is frequently described in patients with pancreatic ductal adenocarcinoma (PDAC) and is associated with reduced survival and quality of life. Unfortunately, the therapeutic options of this multi-factorial and complex syndrome are limited. This is due to the fact that, despite extensive preclinical and clinical research, the underlying pathological mechanisms leading to PDAC-associated cachexia are still not fully understood. ⋯ However, recent studies have demonstrated that multidimensional therapeutic modalities are able to alleviate pancreatic cancer-associated cachexia and ultimately improve patients' outcome. In this current review, we propose a stepwise and pragmatic approach to facilitate and standardize the treatment of cachexia in pancreatic cancer patients. This strategy consists of nutritional, dietary, pharmacological, physical and psychological methods.
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World J. Gastroenterol. · Jul 2014
ReviewNon-alcoholic fatty liver disease and obesity: biochemical, metabolic and clinical presentations.
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. Presentation of the disease ranges from simple steatosis to non-alcoholic steatohepatitis (NASH). NAFLD is a hepatic manifestation of metabolic syndrome that includes central abdominal obesity along with other components. ⋯ Treatment for NAFLD and NASH involves weight reduction through lifestyle modifications, anti-obesity medication and bariatric surgery. This article reviews the available information on the biochemical and metabolic phenotypes associated with obesity and fatty liver disease. The relative contribution of visceral and liver fat to insulin resistance is discussed, and recommendations for clinical evaluation of affected individuals is provided.