World journal of gastroenterology : WJG
-
World J. Gastroenterol. · Jul 2014
Randomized Controlled Trial Multicenter StudyI.31, a new combination of probiotics, improves irritable bowel syndrome-related quality of life.
To determine the dose-related effects of a novel probiotic combination, I.31, on irritable bowel syndrome (IBS)-related quality of life (IBS-QoL). ⋯ A new combination of three different probiotic bacteria was superior to placebo in improving IBS-related quality of life in patients with IBS and diarrhea.
-
World J. Gastroenterol. · Jul 2014
ReviewModern approach to the clinical management of non-alcoholic fatty liver disease.
Non-alcoholic fatty liver disease (NAFLD) is the most common and emerging form of chronic liver disease worldwide. It includes a wide spectrum of liver diseases ranging from simple fatty liver to steatohepatitis, which may progress to cirrhosis, liver cancer, and liver mortality. Common metabolic diseases, which are well established cardiovascular risk factors, have been associated to NAFLD and cardiovascular disease is the single most important cause of morbidity and mortality in this patient population. ⋯ Metabolic conditions such as diabetes mellitus, obesity, hypertension and hyperlipidemia, should be strongly considered and a multidisciplinary approach should be personalized for individual patients. Treatment of co-morbidities should be regarded as of paramount importance in the management of these patients. The purpose of this review is to examine different approaches for the clinical management of non-alcoholic fatty liver disease.
-
World J. Gastroenterol. · Jul 2014
Prognostic significance of preoperative fibrinogen in patients with colon cancer.
To investigate the prognostic significance of preoperative fibrinogen levels in colon cancer patients. ⋯ Preoperative fibrinogen levels can serve as an independent prognostic marker to evaluate patient response to colon cancer treatment.
-
World J. Gastroenterol. · Jul 2014
Changes in circulating Foxp3(+) regulatory T cells and interleukin-17-producing T helper cells during HBV-related acute-on-chronic liver failure.
To longitudinally investigate cytokine gene expression and protein levels in Th17 and Treg cells, to observe T-cell phenotypes during hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACHBLF) and to analyze changes in Th17 and Treg phenotypes during disease progression. ⋯ Treg and Th17 cells showed changes in genes, protein levels and T cell phenotypes during ACHBLF events. An increased Treg/Th17 ratio was associated with the survival of ACHBLF patients.
-
World J. Gastroenterol. · Jul 2014
APE1 polymorphisms are associated with colorectal cancer susceptibility in Chinese Hans.
To study the association between four base excision repair gene polymorphisms and colorectal cancer risk in a Chinese population. ⋯ APE1 Asp148Glu is associated with increased CRC risk and smoking alters the association between XRCC1 Arg399Gln and CRC risk in the Chinese Han population.