Postgraduate medicine
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Postgraduate medicine · Jan 2021
Lack of residual morning effects of lemborexant treatment for insomnia: summary of findings across 9 clinical trials.
Residual next-day effects of sleep-promoting drugs are common and an important safety issue. Lemborexant is a dual orexin receptor antagonist approved in the United States and Japan for treatment of insomnia in adults. We evaluated the potential of lemborexant for residual morning and next-day effects, including somnolence, based on lemborexant clinical study findings. ⋯ Across 9 clinical studies, lemborexant did not substantially impair next-day functioning among healthy subjects and subjects with insomnia.
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Postgraduate medicine · Jan 2021
Pain severity and healthcare resource utilization in patients with osteoarthritis in the United States.
To evaluate healthcare resource utilization (HCRU) by osteoarthritis (OA) pain severity. ⋯ Greater current pain was associated with more prior HCRU including imaging for monitoring progression, HCP visits including more specialty care, hospitalizations, surgery/planned surgery, and loss of independence due to functional disability. Yet rates of hospitalizations and X-ray use were still sizable even among patients with mild pain. These cross-sectional findings warrant longitudinal assessment to further elucidate the impact of pain on HCRU.
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Postgraduate medicine · Jan 2021
Association between lateral epicondylitis and the risk of herpes zoster development.
Diseases burden is associated with herpes zoster (HZ) development. However, the relationship between lateral epicondylitis (LE) and HZ remains unknown. ⋯ Women with LE had a higher risk of HZ development. HZ vaccination may be needed for the female patients with LE.
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Postgraduate medicine · Jan 2021
Case ReportsPulmonary resection for multiple lung metastasis from ameloblastoma: a rare case report and literature review.
Ameloblastoma is a benign odontogenic epithelial neoplasm. Lung metastasis of ameloblastoma is extremely rare, and its biological behavior is still largely unknown. There is no consensus regarding the best method to treat metastasizing ameloblastoma. ⋯ This is a rare case with multiple lung metastasis from ameloblastoma who was successfully treated with multiple pulmonary resections. The present study indicated that surgery may be considered an appropriate choice for lung metastasis of ameloblastoma.
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Postgraduate medicine · Jan 2021
Exploring patient safety culture in the community pharmacy setting: A national cross-sectional study.
The community pharmacy is one setting that plays a crucial role in patient safety. To develop tailored patient safety improvement programs in this setting, it is essential to know the perspectives of the pharmacies' staffs on patient safety. Thus, in this study, we assessed patient-safety culture in the community pharmacy setting in Saudi Arabia. ⋯ The study revealed that all dimensions are scope for further improvement, and critical consideration ought to be given to the areas of weakness, for the most part in the dimension of Staffing, Work Pressure, and Pace.