Acta neurochirurgica. Supplement
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Acta Neurochir. Suppl. · Jan 2011
Application of pulsed radio frequency to the dorsal horn and dorsal roots.
In the world of neuromodulation for pain management, the new multifunctional electrode presented in this article, together with the associated procedure described, considerably extends the range of therapeutic options in the hands of pain physicians. Besides the definite therapeutic effect, the lower rate of complications and side effects, further factors also make this new procedure and device appear an attractive diagnostic and therapeutic modality.
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Acta Neurochir. Suppl. · Jan 2011
Predictors analysis of symptomatic cerebral vasospasm after subarachnoid hemorrhage.
symptomatic cerebral vasospasm (SCVS) is still lacking in reliable early warning methods and often diagnosed after clinical deterioration of neurological function, making prevention and treatment extremely passive. This study investigates the risk factors relevant to SCVS after subarachnoid hemorrhage (SAH) in order to provide useful information for clinical work. ⋯ SCVS is the final result of multiple factors acting together. Age and modified Fisher grades are independent risk factors to SCVS.
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Acta Neurochir. Suppl. · Jan 2011
Thrombin preconditioning reduces iron-induced brain swelling and brain atrophy.
Cerebral preconditioning with a low dose of thrombin attenuates brain edema induced by intracerebral hemorrhage (ICH), a large dose of thrombin or iron. This study examined whether or not thrombin preconditioning (TPC) reduces neuronal death and brain atrophy caused by iron. The right hippocampus of rats was pretreated with or without thrombin, and iron was then injected into the same location 3 days later. ⋯ We found that TPC reduced neuronal death and brain swelling in the hippocampus 1 day after iron injection, and hippocampal atrophy 7 days later. Western blots showed that thrombin activates p44/42 mitogen-activated protein kinase (p44/42 MAPK) and 70-kDa ribosomal protein S6 kinase (p70 S6K). Our results indicate that TPC reduction of iron-induced neuronal death may be through the p44/42 MAPK /p70 S6K signal transduction pathway.
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Acta Neurochir. Suppl. · Jan 2011
Fever increased in-hospital mortality after subarachnoid hemorrhage.
Fever is a common clinical complication in patients with subarachnoid hemorrhage (SAH), and is usually related to prognosis in early stage of diseases. In our study, we try to help improve the outcome of SAH by assessing possible risk factors for fever and investigating the influence of fever on in-hospital mortality. ⋯ Poor Hunt-Hess grade, presence of IVH and older age are independent predictors of fever in SAH. Fever is closely related to increased in-hospital mortality after SAH.
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In recent years the quality of ultrasound (US) imaging has improved considerably. The integration of three dimensional (3D) US with neuronavigation technology has created an efficient and inexpensive tool for intra-operative imaging in neurosurgery. Our experience is based on more than 900 operations with the intra-operative 3D ultrasound equipment SonoWand® and some operations with the research equipment Custux X. ⋯ Compared to intraoperative magnetic resonance imaging (ioMRI), 3D US technology is advantageous in different ways: it is flexible and can be used in any operation theatre. There is no need for special instruments, and no need for radiologists or technicians. It adds very little extra time to the operation, and the investment-costs are considerably lower than for ioMRI.