Läkartidningen
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General anesthesia induces hypothermia due to decreased metabolic rate and impaired thermoregulation. Adverse effects of hypothermia are common. Many warming devices are in use to prevent heat loss, but little attention has been paid to stimulating the body's own heat generation. ⋯ During anesthesia the thermogenic effect of i.v. amino acids was increased. The results support the existence of an inhibitory action normally exerted by central thermosensors in order to prevent hyperthermia. During anesthesia, central thermosensors are impaired, and hence amino acid thermogenesis is exaggerated, which may prevent hypothermia.
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The neonate has a functional nociceptive system. However, recent research suggests that infants may be more vulnerable to the negative effects of pain than older children and adults. Apart from short-term effects, untreated pain may also have long-term effects, which may later affect neurological development, including the reaction to pain. Despite convincing evidence from recent research, the neonate is still subjected to painful procedures, even surgery, without adequate treatment.
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Despite unprecedented interest in the understanding of pain mechanisms and pain management, a significant number of patients continue to experience unacceptable pain after surgery. An acute pain service (APS) has to include regular pain assessment and documentation, "make pain visible", and bedside teaching of nurses in order to provide safe and cost-effective analgesia. The acute pain team in Orebro includes anaesthesiologists, surgeons, specialist acute pain nurses as well as ward nurses. A combination of less invasive surgery, effective analgesia and strategies for rehabilitation can reduce post-operative morbidity and shorten hospitalization.