British journal of obstetrics and gynaecology
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Br J Obstet Gynaecol · Apr 1998
Prediction of pre-eclampsia, low birthweight for gestation and prematurity by uterine artery blood flow velocity waveforms analysis in low risk nulliparous women.
To assess the performance of four previously reported Doppler abnormalities of uterine artery velocity waveforms (presence of a protodiastolic notch, peak systolic over protodiastolic velocities (A:C ratio) > 2.5, peak systolic over end diastolic velocities (A:B ratio) > 90th centile, resistance index (RI) ([A-B]/A) > or = 0.58) in predicting pre-eclampsia, low birthweight and prematurity. ⋯ Uterine artery Doppler velocimetry waveform analysis does not qualify as a reliable screening test for pre-eclampsia or low birthweight for gestation in low risk pregnancies but may be useful in selected high risk populations.
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Br J Obstet Gynaecol · Mar 1998
Randomized Controlled Trial Clinical TrialBarbados Low Dose Aspirin Study in Pregnancy (BLASP): a randomised trial for the prevention of pre-eclampsia and its complications.
To determine whether prophylactic, low dose controlled-release aspirin improves outcome for pregnant women and their babies in Barbados. ⋯ The results of this study in Barbados do not support the routine use of low dose aspirin for prevention of pre-eclampsia or its complications, confirming results of previous large trials in other settings.
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Br J Obstet Gynaecol · Mar 1998
Randomized Controlled Trial Clinical TrialA randomised controlled trial of intravenous magnesium sulphate versus placebo in the management of women with severe pre-eclampsia.
To determine whether the administration of prophylactic intravenous magnesium sulphate reduces the occurrence of eclampsia in women with severe pre-eclampsia. ⋯ The use of intravenous magnesium sulphate in the management of women with severe pre-eclampsia significantly reduced the development of eclampsia.
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Br J Obstet Gynaecol · Mar 1998
Pregnancy in women with von Willebrand's disease or factor XI deficiency.
To assess the obstetric outcome in women with von Willebrand's disease or factor XI deficiency. ⋯ Pregnancy, labour and the puerperium are associated with significant bleeding problems in women with von Willebrand's disease or factor XI deficiency, but these are largely preventable. Specialist obstetric care in close liaison with the haemophilia centre is essential to minimise maternal and neonatal complications.