Pneumonologia i alergologia polska
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Pneumonol Alergol Pol · Jan 1996
[The influence of organic dust on the chemotaxis of lung cells. Experimental studies].
Mechanisms of chemotaxis of alveolar macrophages (AMs) and neutrophils (PMNs) in response to microbial products derived from organic dust were studied using blindwell chemotaxis chamber technique. Seven different agents (extract and endotoxin of Erwinia herbicola, extracts from Thermoactinomyces vulgaris and Aspergillus fumigatus, thermophilic protease and two preparations of glucans), were used for experiments. ⋯ The generation and release of this activity by AMs may provide a mechanisms for the initiation and amplification of inflammatory reactions in the lung after inhalation of organic dust. Results of these in vitro studies may be relevant to the pathogenesis of alveolitis in organic dust-induced lung diseases.
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Pneumonol Alergol Pol · Jan 1996
Case Reports[Obesity and hypoventilation syndrome; effects of weight loss and treatment with respiratory stimulants].
A 32-year-old, hypertensive, morbidly obese (BMI 49 kg/m2) woman was referred to us suspected of sleep-disordered breathing. Polycythaemia, right heart and respiratory failure, restrictive ventilatory impairment, decreased hypercapnic respiratory drive, high number of very short apneas mostly of central origin (698 vs 530 obstructive), and overnight hypoxaemia were found. ⋯ RBC, spirometry, blood gas analysis, overnight oximetry, hypercapnic respiratory drive and polysomnography showed results within normal limits. Causes, pathophysiology and possible treatment of obesity-hypoventilation syndrome are discussed.