Connecticut medicine
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Conn Med
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We studied the time course of development of tolerance in four terminally ill cancer patients who were treated for intractable pain by intrathecal morphine administered by an implanted catheter and pump. The duration of treatment varied from 1.8 to 10.5 months. ⋯ Hence, for any given patient, the slope of the dose v time curve is effectively a constant over long periods. We also found that patients tolerate very high doses of intrathecal morphine without serious side effects.