Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · May 2007
Randomized Controlled Trial[Effect of fluid resuscitation on extravascular lung water in early stage of septic shock].
To determine the effect of fluid resuscitation on extravascular lung water (EVLW) in early stage of septic shock. ⋯ Fluid resuscitation in early stage of septic shock can improve ITBVI, GEDVI, CI, SI, CVP, with neither increased EVLWI nor worsened oxygenation. EVLWI has significantly negative correlation with PaO(2)/FiO(2) but not with haemodynamics. The increase in PVPI is responsible for the elevation of EVLWI. The patient's outcome is significantly correlated with the value of EVLWI.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · May 2007
[Effect of mesenteric lymph duct ligation on lung injury in hemorrhagic shock rats].
To observe the effect of ligation of mesenteric lymph duct on release of oxygen free radical and inflammatory mediator in lung of rat with serious hemorrhagic shock at different periods, and explore the role of intestinal lymphatic pathway on acute lung injury (ALI). ⋯ The results demonstrate that the ligation of mesenteric lymph duct could ameliorate ALI in rats with serious hemorrhagic shock, and its mechanism might relate with reduction of sequestration of neutrophils, thus reduce the release of TNF-alpha and IL-6, and also reduce the release of oxygen free radical and consumption of SOD. Therefore mesenteric lymphatics might play an important role in pathogenesis of ALI.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · May 2007
[Effect of fluid resuscitation on capillary permeability and vascular endothelial growth factor in dogs with septic shock].
To evaluate the change in capillary permeability and vascular endothelial growth factor (VEGF) after resuscitation with different fluids in dogs with septic shock, and to investigate the possible mechanism and treatment of capillary leak syndrome. ⋯ When the effect of 0.9% NaCl and 7.5% NaCl was compared with HES130/0.4, it is shown that the latter is more superior in decreasing capillary permeability, concentration of VEGF and attenuating pulmonary edema.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · May 2007
[Protective effect of ferulic acid on neuronal apoptosis of spinal cord subsequent to aortic blood cross-clamping in rabbits].
To investigate the protective effect of ferulic acid on neuronal apoptosis of the spinal cord after aortic blood cross-clamping and its mechanism in rabbits. ⋯ Ferulic acid can reduce the spinal cord neuronal apoptosis as a result of aortic occlusion in rabbits. The possible mechanism is that it decreases protein expression of Bax, increases that of Bcl-2 and enhances antioxidation.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · May 2007
[Effects of granulocyte-macrophage colony stimulating factor on nuclear factor-KappaB activation in multiple organs of hemorrhage-induced acute lung injury in mice].
To investigate the effects of nuclear factor-KappaB (NF-KappaB) activation in multiple organs of hemorrhage-induced acute lung injury (ALI) by the specific granulocyte-macrophage colony stimulating factor (GM-CSF)-neutralizing antibody (22E9) and dexamethasone (DEX) in mice. ⋯ 22E9 can inhibit the NF-KappaB activation and inflammatory reaction in multiple organs after hemorrhage-induced ALI and reduce injury in multiple organs, while DEX has no significant effect.