Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · May 2012
[Significance of serum procalcitonin levels in the evaluation of severity and prognosis of patients with systemic inflammatory response syndrome].
To observe the dynamic changes in serum procalcitonin (PCT), C-reactive protein (CRP), and white blood cell (WBC) count in systemic inflammatory response syndrome (SIRS) and their implication in assessment of illness severity and prognosis. ⋯ Serum PCT evaluation may be helpful in differentiating sepsis and non-sepsis at early stage of disease, and also in predicting the severity of the illness and prognosis of SIRS. PCT may be one of the independent risk factors for 28-day survival.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · May 2012
[Changes in serum high mobility group box-1 protein and high-sensitivity C-reactive protein in patients with acute cerebral infarction and their clinical significance].
To study the potential role of high mobility group box-1 protein (HMGB1) and high-sensitivity C-reactive protein (hs-CRP) in acute cerebral infarction (ACI). ⋯ Serum HMGB1 levels (μg/L) at all time points (24 hours: 7.598±0.280, 7th day: 10.491±0.512, 12th day: 5.315±0.224) were significantly higher than those of healthy controls (n=20, 2.994±0.243) and risk factor group in which patients suffered from one risk factor in hypertension, diabetes mellitus, and hyperlipemia at least (n=20, 3.272±0.285), with significant difference (all P<0.01). Serum hs-CRP levels (mg/L, 24 hours: 5.815±0.408, 7th day: 5.063±0.510, 12th day: 2.863±0.297) of the patients were also significantly higher than those of healthy controls (0.642±0.047), with significant difference (all P<0.01), and serum hs-CRP levels on 12th day were similar to that in risk factor group (2.514±0.312), with no significant difference (P>0.05). Serum HMGB1 levels in risk factor group were higher than those in healthy control group but with no significant difference (P>0.05), and serum hs-CRP levels were significantly higher than those in healthy control group (P<0.01). The levels of HMGB1 and hs-CRP in serum were similar between patients with cerebral infarction in vertebral basilar system (n=17) and internal carotid artery system (n=23), and the result showed that the serum HMGB1 or hs-CRP levels had no correlation with infarct site, but had significantly positive correlations with the National Institute of Health stroke scale (NIHSS) score [r1=0.377, P1=0.034; r2=0.353, P2=0.025]. In addition, there was a positive correlation between levels of serum HMGB1 and hs-CRP (r=0.428, P=0.047). CONCLUSIONS; Inflammatory mediators including HMGB1 and hs-CRP might play important roles in the pathogenesis of ACI. They were positively correlated with the severity of ACI, while not correlated with infarct sites. Serum hs-CRP levels in ACI could be of value in early diagnosing of cerebral infarction. Serial determination of serum HMGB1 and hs-CRP levels might be helpful to evaluate the severity and prognosis of ACI.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · May 2012
[The influence of positive end-expiratory pressure on central venous pressure in patients with severe craniocerebral injury].
To observe the impact of positive end-expiratory pressure (PEEP) on central venous pressure (CVP) in mechanically ventilated patients with severe craniocerebral injury. ⋯ CVP values were overestimated during an increase in PEEP in mechanically ventilated patients with severe craniocerebral injury. CVP was increased about 0.368 cm H2O following an increase of PEEP of 1 cm H2O, whereas the values of MAP, HR and SpO2 showed no significant change with increase in PEEP levels. This study could offer a theoretical base in the correct assessment of CVP values at different PEEP levels without discontinuation of mechanical ventilation.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · May 2012
[Value of procalcitonin in the early diagnosis of sepsis in Department of Emergency].
To investigate the value of procalcitonin (PCT) in the early diagnosis and risk stratification in sepsis. ⋯ Serum PCT is a reliable measure in emergency room for early diagnosis of sepsis with high sensitivity and specificity, it could be used as a routine monitoring index in critically ill patients to help assess disease severity in sepsis.