PeerJ
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Blinding is critical to clinical trials because it allows for separation of specific intervention effects from bias, by equalising all factors between groups except for the proposed mechanism of action. Absent or inadequate blinding in clinical trials has consistently been shown in large meta-analyses to result in overestimation of intervention effects. Blinding in dry needling trials, particularly blinding of participants and therapists, is a practical challenge; therefore, specific effects of dry needling have yet to be determined. Despite this, dry needling is widely used by health practitioners internationally for the treatment of pain. This review presents the first empirical account of the influence of blinding on intervention effect estimates in dry needling trials. The aim of this systematic review was to determine whether participant beliefs about group allocation relative to actual allocation (blinding effectiveness), and/or adequacy of blinding procedures, moderated pain outcomes in dry needling trials. ⋯ The small number and size of included trials meant there was insufficient evidence to conclusively determine if a moderating effect of blinding effectiveness or adequacy existed. However, with the caveats of small sample size, generally unclear risk of bias, statistical heterogeneity, potential publication bias, and the limitations of subgroup analyses, the available evidence suggests that inadequate blinding procedures could lead to exaggerated intervention effects in dry needling trials.
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To translate the Perceived Stress Questionnaire (PSQ) into Chinese, validate its reliability and validity in nursing students and investigate the perceived stress level of nursing students. ⋯ The C-PSQ has an appropriate reliability and validity, which means that the scale can be used as a universal tool for psychosomatic studies. The perceived stress of nursing students was relatively high. Further studies are needed.
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Fossil polypterids are mainly represented by disarticulated material, most of them pinnules. However, there is no study that proves the taxonomical validity of these structures. ⋯ Nevertheless, when comparing two different specimens of one species there is little or no interindividual variation, suggesting that pinnule morphology may have taxonomical validity. As the fossil polypterid record is based mainly on the articular head of the pinnules, we suggest caution when describing new taxa, especially if different fragments corresponding to specific positions in the dorsal fin occur in the same locality.
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The variation between the actual and perceived lightness of a stimulus has strong dependency on its background, a phenomena commonly known as lightness induction in the literature of visual neuroscience and psychology. For instance, a gray patch may perceptually appear to be darker in a background while it looks brighter when the background is reversed. In the literature it is further reported that such variation can take place in two possible ways. ⋯ The model assumes that for the White's illusion, where the edges are strong and quite a few, i.e., the spectrum is rich in high frequency components, the inhibitory surround in the classical Difference-of-Gaussians (DoG) filter gets suppressed, and the filter essentially reduces to an adaptive scale Gaussian kernel that brings about lightness assimilation. The linear filter model with a Gaussian kernel is used to simulate the White's illusion phenomena with wide variation of spatial frequency of the background grating as well as the length of the gray patch. The appropriateness of the model is presented through simulation results, which are highly tuned to the present as well as earlier psychometric results.
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Patellofemoral pain (PFP) is often reported as a diffuse pain at the front of the knee during knee-loading activities. A patient's description of pain location and distribution is commonly drawn on paper by clinicians, which is difficult to quantify, report and compare within and between patients. One way of overcoming these potential limitations is to have the patient draw their pain regions using digital platforms, such as personal computer tablets. ⋯ Pain drawings as acquired using paper and computer tablet are equivalent in terms of total area of reported knee pain. The advantages of digital recording platforms, such as quantification and reporting of pain area, could be realized in both research and clinical settings.