Annals of the American Thoracic Society
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Rationale: Interpretation of spirometry is influenced by inherent limitations and by the normal or predicted reference values used. For example, traditional spirometric parameters such as "distal" airflows do not provide sufficient differentiating capacity, especially for mixed patterns or small airway disease. Objectives: We assessed the utility of an alternative spirometric parameter (area under the expiratory flow-volume curve [AEX]) in differentiating between normal, obstruction, restriction, and mixed patterns, as well as in severity stratification of traditional functional impairments. ⋯ Using forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and FEV1/FVC z-scores plus the square root of AEX in a machine learning algorithm, diagnostic categorization of ventilatory impairments was accomplished with very low rates of misclassification (<9%). Especially for mixed ventilatory patterns, the neural network model performed best in improving the rates of diagnostic misclassification. Conclusions: Using a novel approach to lung function assessment in combination with traditional spirometric measurements, AEX differentiates well between normal, obstruction, restriction and mixed impairments, potentially obviating the need for more complex lung volume-based determinations.