Radiology
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MR monitoring of cyclooxygenase-2 inhibition of angiogenesis in a human breast cancer model in rats.
To prospectively evaluate the ability of macromolecular contrast medium (MMCM)-enhanced dynamic magnetic resonance (MR) imaging to depict vascular changes in response to cyclooxygenase-2 (COX-2) inhibition of angiogenesis in a human breast cancer model. ⋯ Dynamic MR imaging revealed microvascular permeability to a high-molecular-weight contrast agent was significantly reduced by treatment with celecoxib.
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The purpose of this HIPAA-compliant study was to prospectively evaluate the technical feasibility of a multistation high-spatial-resolution whole-body magnetic resonance (MR) angiography protocol in which high-acceleration parallel imaging (with acceleration factors of three and four) is performed with a 32-channel 3.0-T MR system. After institutional review board approval and written informed consent were obtained, 10 healthy volunteers (four men and six women aged 23-68 years) and four patients (two men and two women aged 56-79 years) suspected of having peripheral vascular disease underwent multistation whole-body contrast material-enhanced MR angiography. Use of multiarray surface coil technology and highly accelerated generalized autocalibrating partially parallel acquisition enabled the acquisition of isotropic high-spatial-resolution three-dimensional data sets for multiple stations. ⋯ Interobserver agreement was excellent (kappa = 0.92; 95% confidence interval: 0.86, 0.96). Multistation whole-body MR angiography with high-acceleration parallel acquisition is feasible at 3.0 T. Further clinical studies combined with ongoing optimization of radiofrequency systems and coils seem warranted to advance the potential of this technology.
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Randomized Controlled Trial
Sciatica: treatment with intradiscal and intraforaminal injections of steroid and oxygen-ozone versus steroid only.
To prospectively compare the clinical effectiveness of intraforaminal and intradiscal injections of a mixture of a steroid, a local anesthetic, and oxygen-ozone (O(2)-O(3)) (chemodiscolysis) versus intraforaminal and intradiscal injections of a steroid and an anesthetic in the management of radicular pain related to acute lumbar disk herniation. ⋯ Intraforaminal and intradiscal injections of a steroid, an anesthetic, and O(2)-O(3) are more effective at 6 months than injections of only a steroid and an anesthetic in the same sites.
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To prospectively use 3.0-T breath-hold high-spatial-resolution contrast material-enhanced magnetic resonance (MR) angiography with highly accelerated parallel acquisition to image the supraaortic arteries of patients suspected of having arterial occlusive disease. ⋯ By using highly accelerated parallel acquisition, the described 3.0-T contrast-enhanced MR angiographic protocol enabled visualization and characterization of the majority of supraaortic arteries, with diagnostic or excellent image quality (97% of arterial segments) and diagnostic values comparable with those obtained by using CT angiography and DSA for detection of arterial stenoses.
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Comparative Study
Subarachnoid hemorrhage in the subacute stage: elevated apparent diffusion coefficient in normal-appearing brain tissue after treatment.
To prospectively evaluate whether subarachnoid hemorrhage (SAH) is associated with a change in the apparent diffusion coefficient (ADC) in normal-appearing brain parenchyma. ⋯ SAH and its treatment may cause global mild vasogenic edema in white matter and deep gray matter that is undetectable on T2-weighted and diffusion-weighted MR images but is detectable by measuring the ADC value in the subacute stage of SAH.